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- W3138314992 endingPage "3171" @default.
- W3138314992 startingPage "3171" @default.
- W3138314992 abstract "Intra- and extracellular pH regulation is a pivotal function of all cells and tissues. Net outward transport of H+ is a prerequisite for normal physiological function, since a number of intracellular processes, such as metabolism and energy supply, produce acid. In tumor tissues, distorted pH regulation results in extracellular acidification and the formation of a hostile environment in which cancer cells can outcompete healthy local host cells. Cancer cells employ a variety of H+/HCO3−-coupled transporters in combination with intra- and extracellular carbonic anhydrase (CA) isoforms, to alter intra- and extracellular pH to values that promote tumor progression. Many of the transporters could closely associate to CAs, to form a protein complex coined “transport metabolon”. While transport metabolons built with HCO3−-coupled transporters require CA catalytic activity, transport metabolons with monocarboxylate transporters (MCTs) operate independently from CA catalytic function. In this article, we assess some of the processes and functions of CAs for tumor pH regulation and discuss the role of intra- and extracellular pH regulation for cancer pathogenesis and therapeutic intervention." @default.
- W3138314992 created "2021-03-29" @default.
- W3138314992 creator A5071807487 @default.
- W3138314992 creator A5089529779 @default.
- W3138314992 date "2021-03-20" @default.
- W3138314992 modified "2023-10-17" @default.
- W3138314992 title "Proton Transport in Cancer Cells: The Role of Carbonic Anhydrases" @default.
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