Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138340910> ?p ?o ?g. }
- W3138340910 abstract "Acute high-fat diet (aHFD) exposure induces a brief period of hyperphagia before caloric balance is restored. Previous studies have demonstrated that this period of regulation is associated with activation of synaptic N-methyl-D-aspartate (NMDA) receptors on dorsal motor nucleus of the vagus (DMV) neurons, which increases vagal control of gastric functions. Our aim was to test the hypothesis that activation of DMV synaptic NMDA receptors occurs subsequent to activation of extrasynaptic NMDA receptors. Sprague-Dawley rats were fed a control or high-fat diet for 3-5 days prior to experimentation. Whole-cell patch-clamp recordings from gastric-projecting DMV neurons; in vivo recordings of gastric motility, tone, compliance, and emptying; and food intake studies were used to assess the effects of NMDA receptor antagonism on caloric regulation. After aHFD exposure, inhibition of extrasynaptic NMDA receptors prevented the synaptic NMDA receptor-mediated increase in glutamatergic transmission to DMV neurons, as well as the increase in gastric tone and motility, while chronic extrasynaptic NMDA receptor inhibition attenuated the regulation of caloric intake. After aHFD exposure, the regulation of food intake involved synaptic NMDA receptor-mediated currents, which occurred in response to extrasynaptic NMDA receptor activation. Understanding these events may provide a mechanistic basis for hyperphagia and may identify novel therapeutic targets for the treatment of obesity." @default.
- W3138340910 created "2021-03-29" @default.
- W3138340910 creator A5004701708 @default.
- W3138340910 creator A5011163609 @default.
- W3138340910 creator A5051307351 @default.
- W3138340910 creator A5063758470 @default.
- W3138340910 date "2021-05-10" @default.
- W3138340910 modified "2023-09-24" @default.
- W3138340910 title "DMV extrasynaptic NMDA receptors regulate caloric intake in rats" @default.
- W3138340910 cites W1483558593 @default.
- W3138340910 cites W149934552 @default.
- W3138340910 cites W1521541843 @default.
- W3138340910 cites W1558985734 @default.
- W3138340910 cites W1562824548 @default.
- W3138340910 cites W1581615324 @default.
- W3138340910 cites W1820680165 @default.
- W3138340910 cites W1921435604 @default.
- W3138340910 cites W1966405653 @default.
- W3138340910 cites W1972665414 @default.
- W3138340910 cites W1973235054 @default.
- W3138340910 cites W1977444960 @default.
- W3138340910 cites W1988535073 @default.
- W3138340910 cites W1992212303 @default.
- W3138340910 cites W2002287054 @default.
- W3138340910 cites W2004085235 @default.
- W3138340910 cites W2008048120 @default.
- W3138340910 cites W2016237476 @default.
- W3138340910 cites W2017172905 @default.
- W3138340910 cites W2018235445 @default.
- W3138340910 cites W2018975566 @default.
- W3138340910 cites W2025498751 @default.
- W3138340910 cites W2033283296 @default.
- W3138340910 cites W2041778509 @default.
- W3138340910 cites W2042021451 @default.
- W3138340910 cites W2043058195 @default.
- W3138340910 cites W2046745069 @default.
- W3138340910 cites W2048533752 @default.
- W3138340910 cites W2048709471 @default.
- W3138340910 cites W2049069390 @default.
- W3138340910 cites W2058493084 @default.
- W3138340910 cites W2065079450 @default.
- W3138340910 cites W2065503347 @default.
- W3138340910 cites W2073508793 @default.
- W3138340910 cites W2083763054 @default.
- W3138340910 cites W2085771633 @default.
- W3138340910 cites W2094080937 @default.
- W3138340910 cites W2097194551 @default.
- W3138340910 cites W2097526241 @default.
- W3138340910 cites W2102823351 @default.
- W3138340910 cites W2104417933 @default.
- W3138340910 cites W2104777114 @default.
- W3138340910 cites W2106038862 @default.
- W3138340910 cites W2108629233 @default.
- W3138340910 cites W2110350185 @default.
- W3138340910 cites W2111377773 @default.
- W3138340910 cites W2111565681 @default.
- W3138340910 cites W2117271843 @default.
- W3138340910 cites W2120508643 @default.
- W3138340910 cites W2121598229 @default.
- W3138340910 cites W2123609069 @default.
- W3138340910 cites W2127709546 @default.
- W3138340910 cites W2130705536 @default.
- W3138340910 cites W2130935482 @default.
- W3138340910 cites W2145425898 @default.
- W3138340910 cites W2152402650 @default.
- W3138340910 cites W2154722810 @default.
- W3138340910 cites W2157297172 @default.
- W3138340910 cites W2164938885 @default.
- W3138340910 cites W2166097552 @default.
- W3138340910 cites W2171083641 @default.
- W3138340910 cites W2171189984 @default.
- W3138340910 cites W2180465677 @default.
- W3138340910 cites W2248498095 @default.
- W3138340910 cites W2254633115 @default.
- W3138340910 cites W2257440853 @default.
- W3138340910 cites W2306831853 @default.
- W3138340910 cites W2343622098 @default.
- W3138340910 cites W2398523712 @default.
- W3138340910 cites W2411757586 @default.
- W3138340910 cites W2412096695 @default.
- W3138340910 cites W2533123739 @default.
- W3138340910 cites W2605970404 @default.
- W3138340910 cites W2740804658 @default.
- W3138340910 cites W2761961128 @default.
- W3138340910 cites W2784409775 @default.
- W3138340910 cites W2886309153 @default.
- W3138340910 cites W2968645128 @default.
- W3138340910 cites W2974847145 @default.
- W3138340910 cites W4248492965 @default.
- W3138340910 cites W4296816736 @default.
- W3138340910 doi "https://doi.org/10.1172/jci.insight.139785" @default.
- W3138340910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8262316" @default.
- W3138340910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33764905" @default.
- W3138340910 hasPublicationYear "2021" @default.
- W3138340910 type Work @default.
- W3138340910 sameAs 3138340910 @default.
- W3138340910 citedByCount "5" @default.
- W3138340910 countsByYear W31383409102021 @default.
- W3138340910 countsByYear W31383409102022 @default.
- W3138340910 countsByYear W31383409102023 @default.