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- W3138342009 abstract "Post-transplant hepatitis B (HBV) is a less important clinical problem than in the early years of transplantation. Using a combination prophylaxis with hepatitis B immune globulin (HBIG) and nucleos(t)ide analogues, liver transplantation (LT) in patients with HBV produces survival rates at 5 years in over 80% and recurrence rates below 5%. Recurrence of HBV infection after LT is commonly defined as the reappearance of circulating hepatitis B surface antigen with or without detectable HBV DNA. The association between hepatocellular carcinoma (HCC) and HBV recurrence and the detection of cccDNA in HCC cells suggest the possibility of viral replication in tumor cells, which would then act as a viral reservoir. Patients with high levels of HBV replication before transplantation have a high risk for recurrence when hepatitis B immune globulin is discontinued. The growing organ shortage and the improved possibilities of HBV therapy favor the use of marginal grafts such as grafts from HBsAg-negative, anti-HBc-positive donors." @default.
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- W3138342009 date "2021-03-12" @default.
- W3138342009 modified "2023-09-24" @default.
- W3138342009 title "Management of Hepatitis B Virus Infection Post Transplantation" @default.
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