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- W3138344015 abstract "Abstract Apical constriction driven by non-muscle myosin II (“myosin”) provides a well-conserved mechanism to mediate epithelial folding. It remains unclear how contractile forces near the apical surface of a cell sheet drive out-of-plane bending of the sheet and whether myosin contractility is required throughout folding. By optogenetic-mediated acute inhibition of myosin, we find that during Drosophila mesoderm invagination, myosin contractility is critical to prevent tissue relaxation during the early, “priming” stage of folding but is dispensable for the actual folding step after the tissue passes through a stereotyped transitional configuration, suggesting that the mesoderm is mechanically bistable during gastrulation. Combining computer modeling and experimental measurements, we show that the observed mechanical bistability arises from an in-plane compression from the surrounding ectoderm, which promotes mesoderm invagination by facilitating a buckling transition. Our results indicate that Drosophila mesoderm invagination requires a joint action of local apical constriction and global in-plane compression to trigger epithelial buckling." @default.
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- W3138344015 date "2021-03-19" @default.
- W3138344015 modified "2023-10-18" @default.
- W3138344015 title "Mechanical bistability enabled by ectodermal compression facilitatesDrosophilamesoderm invagination" @default.
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- W3138344015 doi "https://doi.org/10.1101/2021.03.18.435928" @default.
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