Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138346787> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W3138346787 endingPage "S129" @default.
- W3138346787 startingPage "S129" @default.
- W3138346787 abstract "Accumulating evidences have disclosed the important role of gut microbiome in modulating response of immunotherapy in the patients with lung cancer. However, research exploring the relationship of intestinal flora and chemotherapy is still limited. The study is to investigate the correlation between intestinal flora and chemotherapy efficacy in locally advanced and advanced lung cancer. We analyzed baseline stool samples from lung cancer patients before chemotherapy treatment, through metagenomics of gut microbiota. The composition, diversity, function and metabolic pathway of microbial communities were compared among patients with different chemotherapy response. From September 1, 2018 to September 30, 2019, 64 consecutive lung cancer patients treated with chemotherapy were included into this study. All patients provided the stool samples. 33 of 64 patients responded to treatment (responders) and another 31 patients didn’t (non-responders). The median progression-free survival was 7 months (range, 1.5-14.5). Streptococcus_mutans (P=0.026) and Enterococcus_casseliflavus (P=0.049) were enriched in responders, while 11 bacteria including Leuconostoc_lactis (P=0.002) were enriched in non-responders. Functional analysis of metabolic pathways revealed that L-glutamate degradation VIII pathway was enriched in responders (P=0.014), and 3 pathways including C4 photosynthetic carbon assimilation cycle were enriched in non-responders (P<0.05). Patients enriched with 5 bacterial species, such as Turicibacter_sanguinis (P=0.008) had longer progression-free survival than those enriched in the 7 bacteria including Streptococcus_anginosus (P=0.013) (HR, 0.189; 95% CI, 0.092-0.387; P< 0.0001). Purine nucleobases degradation I and other 4 metabolic pathways were enriched in lung cancer patients with longer progression-free survival (P<0.05). In addition, significant associations of certain bacterial species with clinical parameters such as pathological pattern were observed by spearman correlation analysis. The study indicated that specific intestinal bacteria may be associated with the clinical outcome of locally advanced and advanced lung cancer patients with chemotherapy, which need to be validated by prospective and large samples studies." @default.
- W3138346787 created "2021-03-29" @default.
- W3138346787 creator A5006242866 @default.
- W3138346787 creator A5013915557 @default.
- W3138346787 creator A5030289654 @default.
- W3138346787 creator A5059704072 @default.
- W3138346787 creator A5079613915 @default.
- W3138346787 creator A5088444060 @default.
- W3138346787 date "2021-03-01" @default.
- W3138346787 modified "2023-09-25" @default.
- W3138346787 title "MA01.03 The Role of Gut Microbiome in the Efficacy of Chemotherapy in Patients With Locally Advanced and Advanced Lung Cancer" @default.
- W3138346787 doi "https://doi.org/10.1016/j.jtho.2021.01.199" @default.
- W3138346787 hasPublicationYear "2021" @default.
- W3138346787 type Work @default.
- W3138346787 sameAs 3138346787 @default.
- W3138346787 citedByCount "0" @default.
- W3138346787 crossrefType "journal-article" @default.
- W3138346787 hasAuthorship W3138346787A5006242866 @default.
- W3138346787 hasAuthorship W3138346787A5013915557 @default.
- W3138346787 hasAuthorship W3138346787A5030289654 @default.
- W3138346787 hasAuthorship W3138346787A5059704072 @default.
- W3138346787 hasAuthorship W3138346787A5079613915 @default.
- W3138346787 hasAuthorship W3138346787A5088444060 @default.
- W3138346787 hasBestOaLocation W31383467871 @default.
- W3138346787 hasConcept C126322002 @default.
- W3138346787 hasConcept C143121216 @default.
- W3138346787 hasConcept C143998085 @default.
- W3138346787 hasConcept C203014093 @default.
- W3138346787 hasConcept C2776256026 @default.
- W3138346787 hasConcept C2776694085 @default.
- W3138346787 hasConcept C539455810 @default.
- W3138346787 hasConcept C60644358 @default.
- W3138346787 hasConcept C71924100 @default.
- W3138346787 hasConcept C86803240 @default.
- W3138346787 hasConcept C90924648 @default.
- W3138346787 hasConceptScore W3138346787C126322002 @default.
- W3138346787 hasConceptScore W3138346787C143121216 @default.
- W3138346787 hasConceptScore W3138346787C143998085 @default.
- W3138346787 hasConceptScore W3138346787C203014093 @default.
- W3138346787 hasConceptScore W3138346787C2776256026 @default.
- W3138346787 hasConceptScore W3138346787C2776694085 @default.
- W3138346787 hasConceptScore W3138346787C539455810 @default.
- W3138346787 hasConceptScore W3138346787C60644358 @default.
- W3138346787 hasConceptScore W3138346787C71924100 @default.
- W3138346787 hasConceptScore W3138346787C86803240 @default.
- W3138346787 hasConceptScore W3138346787C90924648 @default.
- W3138346787 hasIssue "3" @default.
- W3138346787 hasLocation W31383467871 @default.
- W3138346787 hasOpenAccess W3138346787 @default.
- W3138346787 hasPrimaryLocation W31383467871 @default.
- W3138346787 hasRelatedWork W2055244776 @default.
- W3138346787 hasRelatedWork W2348529436 @default.
- W3138346787 hasRelatedWork W2358450743 @default.
- W3138346787 hasRelatedWork W2381460883 @default.
- W3138346787 hasRelatedWork W2407189953 @default.
- W3138346787 hasRelatedWork W2413020017 @default.
- W3138346787 hasRelatedWork W2480785262 @default.
- W3138346787 hasRelatedWork W2589143814 @default.
- W3138346787 hasRelatedWork W2987628800 @default.
- W3138346787 hasRelatedWork W3032349186 @default.
- W3138346787 hasVolume "16" @default.
- W3138346787 isParatext "false" @default.
- W3138346787 isRetracted "false" @default.
- W3138346787 magId "3138346787" @default.
- W3138346787 workType "article" @default.