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- W3138350580 endingPage "1172" @default.
- W3138350580 startingPage "1160" @default.
- W3138350580 abstract "Rolling circle replication (RCR), including rolling circle amplification (RCA) and rolling circle transcription (RCT), is an isothermal enzymatic reaction. Because of its high amplification efficiency, RCR is a powerful biosensing tool for detecting biomolecules. In recent years, RCR has also been extended to the field of bioimaging to better understand biological pathways. Furthermore, RCR provides a simple technique to design and generate DNA/RNA structures with unique advantages in delivering drugs and enhanced targeting ability. In this review, we introduce the fundamentals of RCR and describe the most recent advances in RCR-based detection methods and delivery vehicles for biosensing, bioimaging, and biomedicine. Finally, some challenges and further opportunities of RCR-based biotechnology are discussed." @default.
- W3138350580 created "2021-03-29" @default.
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- W3138350580 date "2021-11-01" @default.
- W3138350580 modified "2023-10-03" @default.
- W3138350580 title "Rolling Circle Replication for Biosensing, Bioimaging, and Biomedicine" @default.
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- W3138350580 doi "https://doi.org/10.1016/j.tibtech.2021.02.007" @default.
- W3138350580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33715868" @default.
- W3138350580 hasPublicationYear "2021" @default.
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