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- W3138366950 endingPage "641" @default.
- W3138366950 startingPage "631" @default.
- W3138366950 abstract "The diagnosis of chromosomal mosaicism in the preimplantation and prenatal stage is fraught with uncertainty and multiple factors need to be considered in order to gauge the likely impact. The clinical effects of chromosomal mosaicism are directly linked to the type of the imbalance (size, gene content, and copy number), the timing of the initial event leading to mosaicism during embryogenesis/fetal development, the distribution of the abnormal cells throughout the various tissues within the body as well as the ratio of normal/abnormal cells within each of those tissues. Additional factors such as assay noise and culture artifacts also have an impact on the significance and management of mosaic cases. Genetic counseling is an important part of educating patients about the likelihood of having a liveborn with a chromosome abnormality and these risks differ according to the time of ascertainment and the tissue where the mosaic cells were initially discovered. Each situation needs to be assessed on a case-by-case basis and counseled accordingly. This review will discuss the clinical impact of finding mosaicism through: embryo biopsy, chorionic villus sampling, amniocentesis, and noninvasive prenatal testing using cell-free DNA." @default.
- W3138366950 created "2021-03-29" @default.
- W3138366950 creator A5013222619 @default.
- W3138366950 creator A5053909568 @default.
- W3138366950 creator A5058906995 @default.
- W3138366950 creator A5077891969 @default.
- W3138366950 date "2021-03-22" @default.
- W3138366950 modified "2023-10-14" @default.
- W3138366950 title "Chromosomal mosaicism: Origins and clinical implications in preimplantation and prenatal diagnosis" @default.
- W3138366950 cites W1680591717 @default.
- W3138366950 cites W1871011023 @default.
- W3138366950 cites W1946360318 @default.
- W3138366950 cites W1964675801 @default.
- W3138366950 cites W1965715692 @default.
- W3138366950 cites W1975630843 @default.
- W3138366950 cites W1981125107 @default.
- W3138366950 cites W1985997696 @default.
- W3138366950 cites W1987488018 @default.
- W3138366950 cites W1988773194 @default.
- W3138366950 cites W1989768423 @default.
- W3138366950 cites W1997442821 @default.
- W3138366950 cites W2003538821 @default.
- W3138366950 cites W2005987382 @default.
- W3138366950 cites W2007526322 @default.
- W3138366950 cites W2010466566 @default.
- W3138366950 cites W2015216945 @default.
- W3138366950 cites W2021905950 @default.
- W3138366950 cites W2024410700 @default.
- W3138366950 cites W2026015523 @default.
- W3138366950 cites W2029273230 @default.
- W3138366950 cites W2030146959 @default.
- W3138366950 cites W2039242083 @default.
- W3138366950 cites W2040269748 @default.
- W3138366950 cites W2045802318 @default.
- W3138366950 cites W2046031540 @default.
- W3138366950 cites W2050742871 @default.
- W3138366950 cites W2070486833 @default.
- W3138366950 cites W2071549738 @default.
- W3138366950 cites W2077259940 @default.
- W3138366950 cites W2089864649 @default.
- W3138366950 cites W2098476695 @default.
- W3138366950 cites W2106530124 @default.
- W3138366950 cites W2110742807 @default.
- W3138366950 cites W2112932434 @default.
- W3138366950 cites W2123136185 @default.
- W3138366950 cites W2138274499 @default.
- W3138366950 cites W2144252620 @default.
- W3138366950 cites W2146921721 @default.
- W3138366950 cites W2158261713 @default.
- W3138366950 cites W2169384571 @default.
- W3138366950 cites W2169423456 @default.
- W3138366950 cites W2175576391 @default.
- W3138366950 cites W2176640038 @default.
- W3138366950 cites W2177179199 @default.
- W3138366950 cites W2398172526 @default.
- W3138366950 cites W2410181392 @default.
- W3138366950 cites W2469584859 @default.
- W3138366950 cites W2529983961 @default.
- W3138366950 cites W2586966667 @default.
- W3138366950 cites W2595176742 @default.
- W3138366950 cites W2604417639 @default.
- W3138366950 cites W2604999910 @default.
- W3138366950 cites W2606503284 @default.
- W3138366950 cites W2609225490 @default.
- W3138366950 cites W2620747209 @default.
- W3138366950 cites W2745617763 @default.
- W3138366950 cites W2750712999 @default.
- W3138366950 cites W2753179511 @default.
- W3138366950 cites W2765822216 @default.
- W3138366950 cites W2774078682 @default.
- W3138366950 cites W2785247518 @default.
- W3138366950 cites W2786887716 @default.
- W3138366950 cites W2787357572 @default.
- W3138366950 cites W2800242374 @default.
- W3138366950 cites W2810978880 @default.
- W3138366950 cites W2892616311 @default.
- W3138366950 cites W2894027174 @default.
- W3138366950 cites W2897782607 @default.
- W3138366950 cites W2899738183 @default.
- W3138366950 cites W2899854920 @default.
- W3138366950 cites W2901190885 @default.
- W3138366950 cites W2913364560 @default.
- W3138366950 cites W2949217660 @default.
- W3138366950 cites W2954504411 @default.
- W3138366950 cites W2966417962 @default.
- W3138366950 cites W2967194441 @default.
- W3138366950 cites W2969213901 @default.
- W3138366950 cites W2975050929 @default.
- W3138366950 cites W2975979611 @default.
- W3138366950 cites W2976660977 @default.
- W3138366950 cites W2981684336 @default.
- W3138366950 cites W2984434858 @default.
- W3138366950 cites W3002776410 @default.
- W3138366950 cites W3004848573 @default.
- W3138366950 cites W3008304880 @default.
- W3138366950 cites W3013478170 @default.
- W3138366950 cites W3014803194 @default.
- W3138366950 cites W3035649665 @default.