Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138370909> ?p ?o ?g. }
- W3138370909 endingPage "402" @default.
- W3138370909 startingPage "357" @default.
- W3138370909 abstract "Type 2 diabetes (T2D), a heterogeneous disorder derived from metabolic dysfunctions, leads to a glucose overflow in the circulation due to both defective insulin secretion and peripheral insulin resistance. One of the critical risk factor for T2D is obesity, which represents a global epidemic that has nearly tripled since 1975. Obesity is characterized by chronically elevated free fatty acid (FFA) levels, which cause deleterious effects on glucose homeostasis referred to as lipotoxicity. Here, we review the physiological FFA roles onto glucose-stimulated insulin secretion (GSIS) and the pathological ones affecting many steps of the mechanisms and modulation of GSIS. We also describe in vitro and in vivo experimental evidences addressing lipotoxicity in β-cells and the role of saturation and chain length of FFA on the potency of GSIS stimulation. The molecular mechanisms underpinning lipotoxic-β-cell dysfunction are also reviewed. Among them, endoplasmic reticulum stress, oxidative stress and mitochondrial dysfunction, inflammation, impaired autophagy and β-cell dedifferentiation. Finally therapeutic strategies for the β-cells dysfunctions such as the use of metformin, glucagon-like peptide 1, thiazolidinediones, anti-inflammatory drugs, chemical chaperones and weight are discussed." @default.
- W3138370909 created "2021-03-29" @default.
- W3138370909 creator A5010444033 @default.
- W3138370909 creator A5056682612 @default.
- W3138370909 creator A5058317095 @default.
- W3138370909 creator A5068264957 @default.
- W3138370909 creator A5080905429 @default.
- W3138370909 creator A5086507419 @default.
- W3138370909 date "2021-01-01" @default.
- W3138370909 modified "2023-10-04" @default.
- W3138370909 title "Molecular mechanisms of lipotoxicity-induced pancreatic β-cell dysfunction" @default.
- W3138370909 cites W1156331671 @default.
- W3138370909 cites W1490541298 @default.
- W3138370909 cites W1499384204 @default.
- W3138370909 cites W1506774487 @default.
- W3138370909 cites W1525779234 @default.
- W3138370909 cites W1562122315 @default.
- W3138370909 cites W1569469862 @default.
- W3138370909 cites W1572077460 @default.
- W3138370909 cites W1574174694 @default.
- W3138370909 cites W1599581161 @default.
- W3138370909 cites W1671926542 @default.
- W3138370909 cites W1712420722 @default.
- W3138370909 cites W1776131825 @default.
- W3138370909 cites W1913661755 @default.
- W3138370909 cites W1965785955 @default.
- W3138370909 cites W1965888721 @default.
- W3138370909 cites W1967659527 @default.
- W3138370909 cites W1967766455 @default.
- W3138370909 cites W1967827418 @default.
- W3138370909 cites W1968346730 @default.
- W3138370909 cites W1969223307 @default.
- W3138370909 cites W1970094644 @default.
- W3138370909 cites W1970420856 @default.
- W3138370909 cites W1971542372 @default.
- W3138370909 cites W1971690212 @default.
- W3138370909 cites W1971701221 @default.
- W3138370909 cites W1972230452 @default.
- W3138370909 cites W1973045246 @default.
- W3138370909 cites W1976315274 @default.
- W3138370909 cites W1978998500 @default.
- W3138370909 cites W1983336199 @default.
- W3138370909 cites W1984413737 @default.
- W3138370909 cites W1986025611 @default.
- W3138370909 cites W1989478714 @default.
- W3138370909 cites W1990045305 @default.
- W3138370909 cites W1990586051 @default.
- W3138370909 cites W1990902267 @default.
- W3138370909 cites W1992829742 @default.
- W3138370909 cites W1995573327 @default.
- W3138370909 cites W1996649880 @default.
- W3138370909 cites W1999927420 @default.
- W3138370909 cites W2000084601 @default.
- W3138370909 cites W2001252698 @default.
- W3138370909 cites W2002711503 @default.
- W3138370909 cites W2003524154 @default.
- W3138370909 cites W2006053538 @default.
- W3138370909 cites W2006849116 @default.
- W3138370909 cites W2013048175 @default.
- W3138370909 cites W2013996883 @default.
- W3138370909 cites W2014391949 @default.
- W3138370909 cites W2014506057 @default.
- W3138370909 cites W2017779665 @default.
- W3138370909 cites W2017975911 @default.
- W3138370909 cites W2018232315 @default.
- W3138370909 cites W2019925176 @default.
- W3138370909 cites W2020468088 @default.
- W3138370909 cites W2021925516 @default.
- W3138370909 cites W2022336683 @default.
- W3138370909 cites W2022512550 @default.
- W3138370909 cites W2025607561 @default.
- W3138370909 cites W2030079903 @default.
- W3138370909 cites W2030287946 @default.
- W3138370909 cites W2032125422 @default.
- W3138370909 cites W2032451121 @default.
- W3138370909 cites W2033627840 @default.
- W3138370909 cites W2034218807 @default.
- W3138370909 cites W2034359103 @default.
- W3138370909 cites W2035282582 @default.
- W3138370909 cites W2035339090 @default.
- W3138370909 cites W2036848107 @default.
- W3138370909 cites W2037802736 @default.
- W3138370909 cites W2037884311 @default.
- W3138370909 cites W2038018821 @default.
- W3138370909 cites W2039270400 @default.
- W3138370909 cites W2039531356 @default.
- W3138370909 cites W2040114107 @default.
- W3138370909 cites W2041129796 @default.
- W3138370909 cites W2042095080 @default.
- W3138370909 cites W2044131015 @default.
- W3138370909 cites W2045838013 @default.
- W3138370909 cites W2049753884 @default.
- W3138370909 cites W2052344684 @default.
- W3138370909 cites W2053706106 @default.
- W3138370909 cites W2053984056 @default.
- W3138370909 cites W2054979846 @default.
- W3138370909 cites W2056823373 @default.
- W3138370909 cites W2057521072 @default.