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• W3138370960 abstract "In patients with SSc, the coexistence of ANCA-associated vasculitis (SSc-AAV) has been reported to be associated with a severe disease course, including significant pulmonary and renal involvement. The presence of ANCA is not uncommon in patients with SSc, and therefore clinicians must maintain a high index of clinical suspicion about SSc-AAV. p-ANCA and anti-myeloperoxidase antibodies are the most common antibodies observed. Patients typically present with clinical features of microscopic polyangiitis or renal-limited vasculitis. There are multiple areas of potential interaction in the pathogenesis of SSc and AAV, which can exacerbate/compound vascular disease. In addition, similar patterns of major internal organ involvement (e.g. lung and kidneys) are seen in both conditions. We highlight a diagnostic approach to SSc-AAV and the paucity of data to inform management. As such, SSc-AAV is typically treated as per isolated AAV, which can potentially be hazardous in patients with SSc (e.g. due to the association between high-dose steroid and scleroderma renal crisis). We propose that this rare clinical entity warrants rigorous investigation, including definition of a therapeutic strategy to ameliorate the potentially devastating combination of pathologies in SSc-AAV." @default.
• W3138370960 created "2021-03-29" @default.
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• W3138370960 date "2021-03-21" @default.
• W3138370960 modified "2023-10-18" @default.
• W3138370960 title "ANCA in systemic sclerosis, when vasculitis overlaps with vasculopathy: a devastating combination of pathologies" @default.
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• W3138370960 doi "https://doi.org/10.1093/rheumatology/keab278" @default.
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• W3138370960 hasPublicationYear "2021" @default.
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