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- W3138455501 abstract "Innate ImmunityAfter treatment with antiretroviral therapy, HIV-1 wild-type and escape variants can persist in a latent form, especially within CD4+ T cells, hindering efforts to eradicate the virus. Q. Wang et al. found that human CARD8, a member of the caspase recruitment domain (CARD)–containing family of innate immune sensors, is activatable by direct proteolysis of its N-terminus by HIV-1 protease. This cleavage should result in the programmed cell death of infected cells, but HIV-1 protease remains inactive and undetected as a subunit of the unprocessed Gag-Pol polyprotein. However, when infected cells were treated with non-nucleoside reverse transcriptase inhibitors, intracellular Gag-Pol dimerization was enhanced, resulting in CARD8-mediated caspase activation and pyroptosis. Targeting this pathway may be a promising way to eliminate residual HIV-1 in patients.Science , this issue p. [eabe1707][1] [1]: /lookup/doi/10.1126/science.abe1707" @default.
- W3138455501 created "2021-03-29" @default.
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- W3138455501 date "2021-03-18" @default.
- W3138455501 modified "2023-09-25" @default.
- W3138455501 title "Eradicating the last vestiges of HIV" @default.
- W3138455501 doi "https://doi.org/10.1126/science.371.6535.1216-p" @default.
- W3138455501 hasPublicationYear "2021" @default.
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