FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138465508> ?p ?o ?g. }

• W3138465508 endingPage "485" @default.
• W3138465508 startingPage "480" @default.
• W3138465508 abstract "Posttraumatic stress disorder (PTSD) symptoms of hyperarousal are mediated through sympathetic nervous system hyperactivity. PTSD symptoms, including distressing thoughts and memories, flashbacks, hyperarousal, and sleep disturbances, have been linked with elevated norepinephrine levels in the cerebrospinal fluid. Clonidine, an alpha2-adrenergic agonist, reduces the release of norepinephrine and has been suggested as a treatment for PTSD. However, literature for use of clonidine in PTSD is limited. The objective of this study was to evaluate clinical records of patients with PTSD treated with clonidine to assess reported efficacy and safety. A cohort of veterans with PTSD treated with clonidine at a midwestern VA hospital between July 2015 and January 2018 were studied retrospectively. Medical records of 79 patients with moderate to severe PTSD symptoms were reviewed by three independent clinicians using the Clinical Global Impressions (CGI) scale to quantify symptom severity (CGI-S) before starting clonidine and subjects’ change in symptoms (CGI-I) after starting clonidine. Data on adverse events were also collected. Subgroup analyses were conducted on the impact of comorbid diagnoses, concurrent medications, and substance use. Mean CGI-S score at baseline was 4.8 (5 = markedly ill). After treatment with low-dose clonidine, 72% of patients experienced improvement, and 49% scored “much improved” or “very much improved.” Adverse effects were reported by 18 out of 79 subjects. In this retrospective analysis of veterans prescribed clonidine for PTSD, CGI-I scores suggested improvement in PTSD symptoms, and minimal side effects were reported. In addition, some comorbid diagnoses and concurrent medications were correlated with variations in outcomes." @default.
• W3138465508 created "2021-03-29" @default.
• W3138465508 creator A5010550893 @default.
• W3138465508 creator A5044120267 @default.
• W3138465508 creator A5054108011 @default.
• W3138465508 creator A5054127828 @default.
• W3138465508 creator A5056879202 @default.
• W3138465508 creator A5068909275 @default.
• W3138465508 date "2021-05-01" @default.
• W3138465508 modified "2023-10-14" @default.
• W3138465508 title "Low-dose clonidine in veterans with Posttraumatic stress disorder" @default.
• W3138465508 cites W1969892668 @default.
• W3138465508 cites W1981983012 @default.
• W3138465508 cites W1995696853 @default.
• W3138465508 cites W2002853385 @default.
• W3138465508 cites W2015497232 @default.
• W3138465508 cites W2018550197 @default.
• W3138465508 cites W2025927654 @default.
• W3138465508 cites W2090860593 @default.
• W3138465508 cites W2094250245 @default.
• W3138465508 cites W2112558862 @default.
• W3138465508 cites W2127369497 @default.
• W3138465508 cites W2128960262 @default.
• W3138465508 cites W2134015193 @default.
• W3138465508 cites W2206866143 @default.
• W3138465508 cites W2296474296 @default.
• W3138465508 cites W2396678243 @default.
• W3138465508 cites W2402748048 @default.
• W3138465508 cites W2508534072 @default.
• W3138465508 cites W2514201488 @default.
• W3138465508 cites W2562873855 @default.
• W3138465508 cites W2742166544 @default.
• W3138465508 cites W2789959403 @default.
• W3138465508 cites W2790793537 @default.
• W3138465508 doi "https://doi.org/10.1016/j.jpsychires.2021.03.008" @default.
• W3138465508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33798975" @default.
• W3138465508 hasPublicationYear "2021" @default.
• W3138465508 type Work @default.
• W3138465508 sameAs 3138465508 @default.
• W3138465508 citedByCount "5" @default.
• W3138465508 countsByYear W31384655082021 @default.
• W3138465508 countsByYear W31384655082022 @default.
• W3138465508 countsByYear W31384655082023 @default.
• W3138465508 crossrefType "journal-article" @default.
• W3138465508 hasAuthorship W3138465508A5010550893 @default.
• W3138465508 hasAuthorship W3138465508A5044120267 @default.
• W3138465508 hasAuthorship W3138465508A5054108011 @default.
• W3138465508 hasAuthorship W3138465508A5054127828 @default.
• W3138465508 hasAuthorship W3138465508A5056879202 @default.
• W3138465508 hasAuthorship W3138465508A5068909275 @default.
• W3138465508 hasConcept C118552586 @default.
• W3138465508 hasConcept C126322002 @default.
• W3138465508 hasConcept C15744967 @default.
• W3138465508 hasConcept C167135981 @default.
• W3138465508 hasConcept C195910791 @default.
• W3138465508 hasConcept C197934379 @default.
• W3138465508 hasConcept C2778399450 @default.
• W3138465508 hasConcept C42219234 @default.
• W3138465508 hasConcept C71924100 @default.
• W3138465508 hasConceptScore W3138465508C118552586 @default.
• W3138465508 hasConceptScore W3138465508C126322002 @default.
• W3138465508 hasConceptScore W3138465508C15744967 @default.
• W3138465508 hasConceptScore W3138465508C167135981 @default.
• W3138465508 hasConceptScore W3138465508C195910791 @default.
• W3138465508 hasConceptScore W3138465508C197934379 @default.
• W3138465508 hasConceptScore W3138465508C2778399450 @default.
• W3138465508 hasConceptScore W3138465508C42219234 @default.
• W3138465508 hasConceptScore W3138465508C71924100 @default.
• W3138465508 hasLocation W31384655081 @default.
• W3138465508 hasOpenAccess W3138465508 @default.
• W3138465508 hasPrimaryLocation W31384655081 @default.
• W3138465508 hasRelatedWork W1506449882 @default.
• W3138465508 hasRelatedWork W1858716145 @default.
• W3138465508 hasRelatedWork W2127172625 @default.
• W3138465508 hasRelatedWork W2316615694 @default.
• W3138465508 hasRelatedWork W2329465690 @default.
• W3138465508 hasRelatedWork W2409218464 @default.
• W3138465508 hasRelatedWork W2748952813 @default.
• W3138465508 hasRelatedWork W2899084033 @default.
• W3138465508 hasRelatedWork W3154734119 @default.
• W3138465508 hasRelatedWork W4309659722 @default.
• W3138465508 hasVolume "137" @default.
• W3138465508 isParatext "false" @default.
• W3138465508 isRetracted "false" @default.
• W3138465508 magId "3138465508" @default.
• W3138465508 workType "article" @default.