Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138476800> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W3138476800 endingPage "62" @default.
- W3138476800 startingPage "56" @default.
- W3138476800 abstract "In the recent years the methods of synthesis and biological activity of phosphorus-containing analogues of biogenic carboxylic acids that are potential anti-metabolites of corresponding endogenous ligands in metabolic processes have been intensively studied. Phosphonacetic (PAA) and phosphonformic acids are the most important biological active phosphorus-containing carboxylic acids. Antiviral activity of phosphonacetic acid and some it’s derivates via inhibition of replication of viral DNA is proven by a number of studies, but searching of efficient and economical method of synthesis of PAA for industrial manufacturing still going on. In this paper, development of the method of synthesis of trimethyl ester of PAA that is the most convenient initial compound for further PAA synthesis is considered. The basis of this development was taken the reaction of interphase alkylation of dimethylphophite by methylchloroacetate without any solvents. Potassium carbonate or sodium carbonate in presence of appropriate phase transfer catalyst was used as a base in this reaction. In the course of the work, the kinetics and selectivity of this reaction were investigated using different bases and the corresponding kinetic curves were obtained. In case of sodium carbonate as a base the effect of using different phase transfer catalysts on yield and selectivity of this reaction was shown. As part of the study, a series of experiments were carried out and optimal process conditions were determined that allow it to be scaled using commercially available substrates and without the use of labor-intensive and high-cost technological methods." @default.
- W3138476800 created "2021-03-29" @default.
- W3138476800 creator A5005805313 @default.
- W3138476800 creator A5016051830 @default.
- W3138476800 creator A5032129161 @default.
- W3138476800 creator A5038801187 @default.
- W3138476800 creator A5064489929 @default.
- W3138476800 creator A5075079654 @default.
- W3138476800 creator A5077732742 @default.
- W3138476800 creator A5081779082 @default.
- W3138476800 date "2019-07-31" @default.
- W3138476800 modified "2023-09-26" @default.
- W3138476800 title "Development of a method of synthesis of trimethyl ester of phosphonacetic acid" @default.
- W3138476800 doi "https://doi.org/10.37952/roi-jbc-01/19-59-7-56" @default.
- W3138476800 hasPublicationYear "2019" @default.
- W3138476800 type Work @default.
- W3138476800 sameAs 3138476800 @default.
- W3138476800 citedByCount "0" @default.
- W3138476800 crossrefType "journal-article" @default.
- W3138476800 hasAuthorship W3138476800A5005805313 @default.
- W3138476800 hasAuthorship W3138476800A5016051830 @default.
- W3138476800 hasAuthorship W3138476800A5032129161 @default.
- W3138476800 hasAuthorship W3138476800A5038801187 @default.
- W3138476800 hasAuthorship W3138476800A5064489929 @default.
- W3138476800 hasAuthorship W3138476800A5075079654 @default.
- W3138476800 hasAuthorship W3138476800A5077732742 @default.
- W3138476800 hasAuthorship W3138476800A5081779082 @default.
- W3138476800 hasBestOaLocation W31384768001 @default.
- W3138476800 hasConcept C118792377 @default.
- W3138476800 hasConcept C134121241 @default.
- W3138476800 hasConcept C134306372 @default.
- W3138476800 hasConcept C161790260 @default.
- W3138476800 hasConcept C164361826 @default.
- W3138476800 hasConcept C178790620 @default.
- W3138476800 hasConcept C185592680 @default.
- W3138476800 hasConcept C191897082 @default.
- W3138476800 hasConcept C192562407 @default.
- W3138476800 hasConcept C21951064 @default.
- W3138476800 hasConcept C2778657360 @default.
- W3138476800 hasConcept C2780291738 @default.
- W3138476800 hasConcept C33923547 @default.
- W3138476800 hasConcept C42058472 @default.
- W3138476800 hasConcept C537181965 @default.
- W3138476800 hasConceptScore W3138476800C118792377 @default.
- W3138476800 hasConceptScore W3138476800C134121241 @default.
- W3138476800 hasConceptScore W3138476800C134306372 @default.
- W3138476800 hasConceptScore W3138476800C161790260 @default.
- W3138476800 hasConceptScore W3138476800C164361826 @default.
- W3138476800 hasConceptScore W3138476800C178790620 @default.
- W3138476800 hasConceptScore W3138476800C185592680 @default.
- W3138476800 hasConceptScore W3138476800C191897082 @default.
- W3138476800 hasConceptScore W3138476800C192562407 @default.
- W3138476800 hasConceptScore W3138476800C21951064 @default.
- W3138476800 hasConceptScore W3138476800C2778657360 @default.
- W3138476800 hasConceptScore W3138476800C2780291738 @default.
- W3138476800 hasConceptScore W3138476800C33923547 @default.
- W3138476800 hasConceptScore W3138476800C42058472 @default.
- W3138476800 hasConceptScore W3138476800C537181965 @default.
- W3138476800 hasIssue "7" @default.
- W3138476800 hasLocation W31384768001 @default.
- W3138476800 hasOpenAccess W3138476800 @default.
- W3138476800 hasPrimaryLocation W31384768001 @default.
- W3138476800 hasRelatedWork W175101248 @default.
- W3138476800 hasRelatedWork W1966274406 @default.
- W3138476800 hasRelatedWork W2020299472 @default.
- W3138476800 hasRelatedWork W2024579545 @default.
- W3138476800 hasRelatedWork W2361382342 @default.
- W3138476800 hasRelatedWork W2374102295 @default.
- W3138476800 hasRelatedWork W2383060123 @default.
- W3138476800 hasRelatedWork W3005527239 @default.
- W3138476800 hasRelatedWork W3120995460 @default.
- W3138476800 hasRelatedWork W3189413206 @default.
- W3138476800 hasVolume "59" @default.
- W3138476800 isParatext "false" @default.
- W3138476800 isRetracted "false" @default.
- W3138476800 magId "3138476800" @default.
- W3138476800 workType "article" @default.