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• W3138493921 abstract "Excessive activation of inflammation in chondrocyte has been considered to be a major reason cause of cellular death and degeneration in osteoarthritis (OA) development. The NLRP3 inflammasome-mediated pyroptosis pathway is closely related to inflammation regulation. This research was conducted to confirm whether NLRP3 expression and activity are impacted in the development of OA and to detect the role of CY-09, a selective and direct inhibitor of NLRP3 in the in vitro and in vivo models of OA. Our findings corroborated that the expression of NLRP3 is stimulated in OA cartilage. CY-09 can maintain extracellular matrix (ECM) homeostasis and regulate inflammation in TNF-α treated chondrocytes via inhibition of NLRP3 inflammasome-mediated pyroptosis. Moreover, the chondrocyte protective effects of CY-09 were further confirmed in vivo in a DMM-induced OA model. In conclusion, our research indicates that experimental OA activated the NLRP3 activity, and pharmacological inhibition of NLRP3 inflammasome activation by CY-09 protects chondrocytes against inflammation and attenuates OA development. • NLRP3 inflammasome is activated in osteoarthritis cartilage. • Pharmacological inhibition of NLRP3 inflammasome by CY-09 alleviates inflammation and degeneration in chondrocytes. • CY-09 inhibits chondrocytes pyroptosis and cell death. • CY-09 attenuates mouse osteoarthritis development." @default.
• W3138493921 created "2021-03-29" @default.
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• W3138493921 date "2021-05-01" @default.
• W3138493921 modified "2023-10-16" @default.
• W3138493921 title "CY-09 attenuates the progression of osteoarthritis via inhibiting NLRP3 inflammasome-mediated pyroptosis" @default.
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• W3138493921 doi "https://doi.org/10.1016/j.bbrc.2021.03.055" @default.
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