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- W3138525048 abstract "The onset and progression of Alzheimer's disease (AD) correlate with neuroinflammatory processes, and inflammatory microglia (MG) are associated with AD-like pathology in a transgenic mouse model. GPNMB was identified as a marker for one subtype (type 1) of rat primary MG (Kawahara et al., GLIA, 2016). However, the function of GPNMB+ type 1 MG in AD brain are largely unknown. We recently reported that memory deficits in 9 month-old APP23 mice, one of the amyloid precursor protein transgenic mice, was reduced in Gpnmb gene heterozygosity (APP23;Gpnmb+/-, 92ndAnnual meeting of the Japanese Pharmacological Society, 2-O-04, 2019). In the present study, we investigated whether Gpnmb gene heterozygosity could affect on memory deficits in 9-month old 5xFAD mice, other AD model mice. We used 5xFAD mice backcrossed to C57BL/6J mice at least for ten generation. Spatial learning and memory was evaluated by Morris Water Maze test. We observed that the number of Nissl-positive neurons in subiculum of 5xFAD mice were lower than those in their wild type littermates. We observed that AD-related memory deficits in 9 month-old 5xFAD mice were decreased in Gpnmb gene heterozygosity (5xFAD;Gpnmb+/-). These finding suggest that GPNMB-positive type 1 MG may be related to memory deficits in AD." @default.
- W3138525048 created "2021-03-29" @default.
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- W3138525048 date "2021-01-01" @default.
- W3138525048 modified "2023-09-26" @default.
- W3138525048 title "Effect of Gpnmb gene on memory deficits in 9 month-old 5xFAD mice" @default.
- W3138525048 doi "https://doi.org/10.1254/jpssuppl.94.0_1-p1-15" @default.
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