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- W3138551348 abstract "A computational framework is developed to enable the characterization of genome-wide, multi-tissue circadian dynamics at the level of functional groupings of genes defined in the context of signaling, cellular/genetic processing and metabolic pathways in rat and mouse. Our aim is to identify how individual genes come together to generate orchestrated rhythmic patterns and how these may vary within and across tissues. We focus our analysis on four tissues (adipose, liver, lung, and muscle). A genome-wide pathway-centric analysis enables us to develop a comprehensive picture on how the observed circadian variation at the individual gene level, orchestrates functional responses at the pathway level. Such pathway-based meta-data analysis enables the rational integration and comparison across platforms and/or experimental designs evaluating emergent dynamics, as opposed to comparisons of individual elements. One of our key findings is that when considering the dynamics at the pathway level, a complex behavior emerges. Our work proposes that tissues tend to coordinate gene's circadian expression in a way that optimizes tissue-specific pathway activity, depending of each tissue's broader role in homeostasis." @default.
- W3138551348 created "2021-03-29" @default.
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- W3138551348 date "2021-03-25" @default.
- W3138551348 modified "2023-10-16" @default.
- W3138551348 title "Pathway-level analysis of genome-wide circadian dynamics in diverse tissues in rat and mouse" @default.
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- W3138551348 doi "https://doi.org/10.1007/s10928-021-09750-3" @default.
- W3138551348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33768484" @default.
- W3138551348 hasPublicationYear "2021" @default.
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