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• W3138554881 endingPage "106960" @default.
• W3138554881 startingPage "106960" @default.
• W3138554881 abstract "Acetaminophen (APAP) is commonly used to treat fever and pain. However, when in overdose is the predominant cause of hepatotoxicity. Despite advances in understanding the mechanisms of APAP-induced hepatotoxicity, the management of acute liver failure remains a challenge. Thus, more relevant experimental models are crucial to provide a better understanding of this condition. The aim of this study is to evaluate the effect of APAP-induced hepatotoxicity on A/J mice using C57BL/6 as reference experimental model. Eight- to ten-week-old male A/J and C57BL/6 mice were treated with APAP (300 or 500 mg/kg) by intraperitoneal injection. After 24 h total blood leukocyte counting, plasma levels of alanine amino transferase (ALT) and aspartate amino transferase (AST), histopathological analysis of liver, lung and kidney were evaluated. A/J mice presented reduction in circulating leukocytes concomitant with the increase in plasma levels of ALT and AST, and liver necrosis when treated with 300 and 500 mg/kg of APAP. C57BL/6 mice presented similar results only with 500 mg/kg of APAP. Our results show that A/J mice have a marked susceptibility to the effects of APAP and could be considered as an experimental model to study APAP-induced toxicity." @default.
• W3138554881 created "2021-03-29" @default.
• W3138554881 creator A5035873821 @default.
• W3138554881 date "2021-03-01" @default.
• W3138554881 modified "2023-09-24" @default.
• W3138554881 title "A/J mice are more susceptible than C57BL/6 to acetaminophen-induced hepatotoxicity" @default.
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• W3138554881 doi "https://doi.org/10.1016/j.vascn.2021.106960" @default.
• W3138554881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33766729" @default.
• W3138554881 hasPublicationYear "2021" @default.
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