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- W3138560437 abstract "Cancer is a public health problem worldwide, and one of the crucial steps within tumor progression is the invasion and metastasis of cancer cells, which are directly related to cancer-associated deaths in patients. Recognizing the molecular markers involved in invasion and metastasis is essential to find targeted therapies in cancer. Interestingly, about 50% of the discovered drugs used in chemotherapy have been obtained from natural sources such as plants, including isoflavonoids. Until now, most drugs are used in chemotherapy targeting proliferation and apoptosis-related molecules. Here, we review recent studies about the effect of isoflavonoids on molecular targets and signaling pathways related to invasion and metastasis in cancer cell cultures, in vivo assays, and clinical trials. This review also reports that glycitein, daidzein, and genistein are the isoflavonoids most studied in preclinical and clinical trials and displayed the most anticancer activity targeting invasion-related proteins such as MMP-2 and MMP-9 and also EMT-associated proteins. Therefore, the diversity of isoflavonoids is promising molecules to be used as chemotherapeutic in invasive cancer. In the future, more clinical trials are needed to validate the effectiveness of the various natural isoflavonoids in the treatment of invasive cancer." @default.
- W3138560437 created "2021-03-29" @default.
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- W3138560437 creator A5050748171 @default.
- W3138560437 creator A5066284919 @default.
- W3138560437 date "2021-03-15" @default.
- W3138560437 modified "2023-10-14" @default.
- W3138560437 title "Natural isoflavonoids in invasive cancer therapy: From bench to bedside" @default.
- W3138560437 cites W1538536694 @default.
- W3138560437 cites W1569631204 @default.
- W3138560437 cites W1738220681 @default.
- W3138560437 cites W1842994045 @default.
- W3138560437 cites W1969500799 @default.
- W3138560437 cites W1974196185 @default.
- W3138560437 cites W1974375115 @default.
- W3138560437 cites W1975162427 @default.
- W3138560437 cites W1979911360 @default.
- W3138560437 cites W1979942274 @default.
- W3138560437 cites W1984292685 @default.
- W3138560437 cites W1987467541 @default.
- W3138560437 cites W1988390261 @default.
- W3138560437 cites W1988414390 @default.
- W3138560437 cites W1990784613 @default.
- W3138560437 cites W1995097523 @default.
- W3138560437 cites W1996796033 @default.
- W3138560437 cites W1998638661 @default.
- W3138560437 cites W2008514427 @default.
- W3138560437 cites W2010214084 @default.
- W3138560437 cites W2011536478 @default.
- W3138560437 cites W2014742104 @default.
- W3138560437 cites W2019524085 @default.
- W3138560437 cites W2022785973 @default.
- W3138560437 cites W2027653913 @default.
- W3138560437 cites W2030786088 @default.
- W3138560437 cites W2032003419 @default.
- W3138560437 cites W2032360583 @default.
- W3138560437 cites W2049009894 @default.
- W3138560437 cites W2049659018 @default.
- W3138560437 cites W2050030436 @default.
- W3138560437 cites W2053358434 @default.
- W3138560437 cites W2058292915 @default.
- W3138560437 cites W2073392595 @default.
- W3138560437 cites W2076480857 @default.
- W3138560437 cites W2077584435 @default.
- W3138560437 cites W2080522575 @default.
- W3138560437 cites W2090000401 @default.
- W3138560437 cites W2091047906 @default.
- W3138560437 cites W2091359397 @default.
- W3138560437 cites W2104217062 @default.
- W3138560437 cites W2107987049 @default.
- W3138560437 cites W2111541751 @default.
- W3138560437 cites W2117692326 @default.
- W3138560437 cites W2119759953 @default.
- W3138560437 cites W2123336936 @default.
- W3138560437 cites W2149342916 @default.
- W3138560437 cites W2153210938 @default.
- W3138560437 cites W2164390929 @default.
- W3138560437 cites W2173771166 @default.
- W3138560437 cites W2209093312 @default.
- W3138560437 cites W2282026089 @default.
- W3138560437 cites W2290658694 @default.
- W3138560437 cites W2300452871 @default.
- W3138560437 cites W2415700893 @default.
- W3138560437 cites W2416252233 @default.
- W3138560437 cites W2471642676 @default.
- W3138560437 cites W2521105332 @default.
- W3138560437 cites W2568746807 @default.
- W3138560437 cites W2583555361 @default.
- W3138560437 cites W2589262512 @default.
- W3138560437 cites W2612253630 @default.
- W3138560437 cites W2618696265 @default.
- W3138560437 cites W2619915307 @default.
- W3138560437 cites W2746354942 @default.
- W3138560437 cites W2754521784 @default.
- W3138560437 cites W2755140013 @default.
- W3138560437 cites W2769426045 @default.
- W3138560437 cites W2786843484 @default.
- W3138560437 cites W2792768542 @default.
- W3138560437 cites W2797883126 @default.
- W3138560437 cites W2805893461 @default.
- W3138560437 cites W2806380271 @default.
- W3138560437 cites W2806456320 @default.
- W3138560437 cites W2889246736 @default.
- W3138560437 cites W2891826094 @default.
- W3138560437 cites W2893052697 @default.
- W3138560437 cites W2899961157 @default.
- W3138560437 cites W2900960361 @default.
- W3138560437 cites W2901068426 @default.
- W3138560437 cites W2901612649 @default.
- W3138560437 cites W2907249221 @default.
- W3138560437 cites W2907688525 @default.