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• W313856217 abstract "Serum undercarboxylated osteocalcin (ucOC) is an index of vitamin K nutritional status in treatment-naive postmenopausal osteoporotic women. The purpose of the present study was to reveal the association between vitamin K nutritional status and serum ucOC concentrations in postmenopausal osteoporotic women taking bisphosphonates. Eighty-six postmenopausal women with osteoporosis (age range: 47-90 years) initiated bisphosphonate treatment. Vitamin K nutritional status was evaluated using a simple vitamin K-intake questionnaire and serum ucOC concentrations were measured after 6 months of treatment. The patients were divided into two groups according to the simple vitamin K-intake questionnaire score: a low vitamin K-intake (score <40) group (n=67) and a normal vitamin K-intake (score >=40) group (n=19). There were no significant differences between the groups in baseline parameters including age, height, body weight, body mass index, serum alkaline phosphatase (ALP), urinary cross-linked N-terminal telopeptides of type I collagen (NTX), and changes in serum ALP and urinary NTX concentrations during the 6-month treatment period. However, the mean serum ucOC concentration after 6 months of treatment was significantly higher in the low vitamin K-intake group (2.79 ng/mL) than in the normal vitamin K-intake group (2.20 ng/mL). These results suggest that 78% of postmenopausal osteoporotic women treated with bisphosphonates may have vitamin K deficiency as indicated by low vitamin K-intake and high serum ucOC concentrations, despite having a similar reduction in bone turnover to women who have normal vitamin K-intake. 血清未羧化的骨钙素(ucOC)是治疗初始的绝经后骨质疏松妇女的维生素K 营 养状况的指标。本研究的目的是揭示服用双磷酸盐的绝经后骨质疏松妇女维生 素K 的营养状况和血清ucOC 的浓度之间的关联。86 位绝经后骨质疏松妇女 开始双磷酸盐治疗(年龄范围47-90 岁)。采用简单的维生素K 摄入量调查问卷 评估维生素K 的营养状况，治疗6 个月后测定血清中ucOC 的浓度。根据简单 的维生素K 摄入量调查问卷评分将患者分为两组：低维生素K 摄入组(得分 <40, n=60)和正常维生素K 摄入组(得分>=40, n=19)。两组患者的基线参数包括 年龄、身高、体重、体质指数、血清碱性磷酸酶(ALP)和尿N-末端肽交联的I 型胶原蛋白(NTX)，以及6 个月治疗期间血清ALP 和尿NTX 浓度的变化之间 没有显著差异。然而治疗6 个月之后，低维生素K 摄入组的平均血清ucOC 浓 度(2.79 ng/mL)显著高于正常维生素K 摄入组(2.20 ng/mL)。这些结果表明，尽 管78%用双磷酸盐治疗的绝经后骨质疏松妇女与正常维生素K 摄入量的妇女 有相似的骨转化降低，但从低维生素K 摄入量和高血清ucOC 浓度看出他们可 能缺乏维生素K。" @default.
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• W313856217 date "2014-01-01" @default.
• W313856217 modified "2023-10-03" @default.
• W313856217 title "Vitamin K nutritional status and undercarboxylated osteocalcin in postmenopausal osteoporotic women treated with bisphosphonates." @default.
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• W313856217 doi "https://doi.org/10.6133/apjcn.2014.23.2.15" @default.
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