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- W3138606989 abstract "Metabolic engineering of microbial hosts for the production of heterologous metabolites and biochemicals is an enabling technology to generate meaningful quantities of desired products that may be otherwise difficult to produce by traditional means. Heterologous metabolite production can be restricted by the accumulation of toxic products within the cell. Efflux transport proteins (transporters) provide a potential solution to facilitate the export of these products, mitigate toxic effects, and enhance production. Recent investigations using knockout lines, heterologous expression, and expression profiling of transporters have revealed candidates that can enhance the export of heterologous metabolites from microbial cell systems. Transporter engineering efforts have revealed that some exhibit flexible substrate specificity and may have broader application potentials. In this Review, the major superfamilies of efflux transporters, their mechanistic modes of action, selection of appropriate efflux transporters for desired compounds, and potential transporter engineering strategies are described for potential applications in enhancing engineered microbial metabolite production. Future studies in substrate recognition, heterologous expression, and combinatorial engineering of efflux transporters will assist efforts to enhance heterologous metabolite production in microbial hosts." @default.
- W3138606989 created "2021-03-29" @default.
- W3138606989 creator A5026343576 @default.
- W3138606989 creator A5034711601 @default.
- W3138606989 creator A5064459880 @default.
- W3138606989 creator A5084184184 @default.
- W3138606989 date "2021-03-22" @default.
- W3138606989 modified "2023-10-02" @default.
- W3138606989 title "Efflux Transporters’ Engineering and Their Application in Microbial Production of Heterologous Metabolites" @default.
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