FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138615756> ?p ?o ?g. }

• W3138615756 endingPage "10" @default.
• W3138615756 startingPage "1" @default.
• W3138615756 abstract "It has been reported that microRNAs (miRs) contribute to several biological functions and are associated with drug resistance in various types of cancer. However, to the best of our knowledge, whether miR‑613 can affect cisplatin (CDDP) sensitivity in non‑small cell lung cancer (NSCLC) remains unknown. Reverse transcription‑quantitative PCR was performed to detect the expression levels of miR‑613 and gap junction α‑1 protein (GJA1) in patients with NSCLC. Cell Counting Kit‑8, colony formation and Transwell assays were employed to exam the effects of miR‑613 and GJA1 on cell functions. Cell apoptosis was analyzed using flow cytometry. An in vivo experiment was conducted to determine the influence of miR‑613 on tumor formation. In the present study, miR‑613 was revealed to be significantly downregulated in lung cancer tissues compared with in adjacent normal tissues, and low miR‑613 expression indicated a poor prognosis. Furthermore, cell proliferation, colony formation and migration of lung cancer cells were inhibited by overexpression of miR‑613. In vivo experiments also demonstrated that miR‑613 could inhibit tumor growth. Moreover, miR‑613 could enhance the negative effects of CDDP on cell proliferation, apoptosis and migration. GJA1 was revealed to be a target gene of miR‑613 and was upregulated in human lung cancer tissues. Rescue experiments demonstrated that miR‑613 increased the chemosensitivity of lung cancer cells by targeting GJA1. Collectively, the results suggested a tumor suppressor role of miR‑613 in NSCLC and indicated that miR‑613 could strengthen CDDP sensitivity in NSCLC cells by targeting GJA1, which may provide a novel therapeutic target for NSCLC." @default.
• W3138615756 created "2021-03-29" @default.
• W3138615756 creator A5025701096 @default.
• W3138615756 creator A5040149104 @default.
• W3138615756 creator A5050299013 @default.
• W3138615756 creator A5060588206 @default.
• W3138615756 date "2021-03-24" @default.
• W3138615756 modified "2023-09-22" @default.
• W3138615756 title "Tumor suppressor miR‑613 induces cisplatin sensitivity in non‑small cell lung cancer cells by targeting GJA1." @default.
• W3138615756 cites W1979779590 @default.
• W3138615756 cites W1985549756 @default.
• W3138615756 cites W1992845343 @default.
• W3138615756 cites W2008657095 @default.
• W3138615756 cites W2017203200 @default.
• W3138615756 cites W2032949102 @default.
• W3138615756 cites W2034194189 @default.
• W3138615756 cites W2051676630 @default.
• W3138615756 cites W2052153483 @default.
• W3138615756 cites W2053182321 @default.
• W3138615756 cites W2078564924 @default.
• W3138615756 cites W2079526610 @default.
• W3138615756 cites W2095810938 @default.
• W3138615756 cites W2107277218 @default.
• W3138615756 cites W2122377564 @default.
• W3138615756 cites W2123393316 @default.
• W3138615756 cites W2126940189 @default.
• W3138615756 cites W2145950952 @default.
• W3138615756 cites W2159640574 @default.
• W3138615756 cites W2162674813 @default.
• W3138615756 cites W2164758046 @default.
• W3138615756 cites W2165837717 @default.
• W3138615756 cites W2416093622 @default.
• W3138615756 cites W2417354618 @default.
• W3138615756 cites W2508893577 @default.
• W3138615756 cites W2588324600 @default.
• W3138615756 cites W2629957220 @default.
• W3138615756 cites W2767126704 @default.
• W3138615756 cites W2791569098 @default.
• W3138615756 cites W2792845052 @default.
• W3138615756 cites W2889646458 @default.
• W3138615756 cites W2890456323 @default.
• W3138615756 cites W2908891533 @default.
• W3138615756 cites W2929491112 @default.
• W3138615756 cites W2944404214 @default.
• W3138615756 cites W3007927709 @default.
• W3138615756 cites W3076312936 @default.
• W3138615756 cites W987886269 @default.
• W3138615756 cites W2918042899 @default.
• W3138615756 cites W56886707 @default.
• W3138615756 doi "https://doi.org/10.3892/mmr.2021.12024" @default.
• W3138615756 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7986010" @default.
• W3138615756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33760215" @default.
• W3138615756 hasPublicationYear "2021" @default.
• W3138615756 type Work @default.
• W3138615756 sameAs 3138615756 @default.
• W3138615756 citedByCount "7" @default.
• W3138615756 countsByYear W31386157562022 @default.
• W3138615756 countsByYear W31386157562023 @default.
• W3138615756 crossrefType "journal-article" @default.
• W3138615756 hasAuthorship W3138615756A5025701096 @default.
• W3138615756 hasAuthorship W3138615756A5040149104 @default.
• W3138615756 hasAuthorship W3138615756A5050299013 @default.
• W3138615756 hasAuthorship W3138615756A5060588206 @default.
• W3138615756 hasConcept C104317684 @default.
• W3138615756 hasConcept C121608353 @default.
• W3138615756 hasConcept C142724271 @default.
• W3138615756 hasConcept C145059251 @default.
• W3138615756 hasConcept C1491633281 @default.
• W3138615756 hasConcept C190283241 @default.
• W3138615756 hasConcept C203014093 @default.
• W3138615756 hasConcept C2776256026 @default.
• W3138615756 hasConcept C2776694085 @default.
• W3138615756 hasConcept C2778239845 @default.
• W3138615756 hasConcept C2781018059 @default.
• W3138615756 hasConcept C29537977 @default.
• W3138615756 hasConcept C502942594 @default.
• W3138615756 hasConcept C54355233 @default.
• W3138615756 hasConcept C553184892 @default.
• W3138615756 hasConcept C55493867 @default.
• W3138615756 hasConcept C62112901 @default.
• W3138615756 hasConcept C67082663 @default.
• W3138615756 hasConcept C71924100 @default.
• W3138615756 hasConcept C86803240 @default.
• W3138615756 hasConceptScore W3138615756C104317684 @default.
• W3138615756 hasConceptScore W3138615756C121608353 @default.
• W3138615756 hasConceptScore W3138615756C142724271 @default.
• W3138615756 hasConceptScore W3138615756C145059251 @default.
• W3138615756 hasConceptScore W3138615756C1491633281 @default.
• W3138615756 hasConceptScore W3138615756C190283241 @default.
• W3138615756 hasConceptScore W3138615756C203014093 @default.
• W3138615756 hasConceptScore W3138615756C2776256026 @default.
• W3138615756 hasConceptScore W3138615756C2776694085 @default.
• W3138615756 hasConceptScore W3138615756C2778239845 @default.
• W3138615756 hasConceptScore W3138615756C2781018059 @default.
• W3138615756 hasConceptScore W3138615756C29537977 @default.
• W3138615756 hasConceptScore W3138615756C502942594 @default.
• W3138615756 hasConceptScore W3138615756C54355233 @default.
• W3138615756 hasConceptScore W3138615756C553184892 @default.

• next