Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138648420> ?p ?o ?g. }
- W3138648420 endingPage "384" @default.
- W3138648420 startingPage "384" @default.
- W3138648420 abstract "Transcranial magnetic stimulation (TMS) is a non-invasive method used to investigate neurophysiological integrity of the human neuromotor system. We describe in detail, the methodology of a single pulse TMS protocol that was performed in a large cohort of people (n = 110) with multiple sclerosis (MS). The aim was to establish and validate a core-set of TMS variables that predicted typical MS clinical outcomes: walking speed, hand dexterity, fatigue, and cognitive processing speed. We provide a brief and simple methodological pipeline to examine excitatory and inhibitory corticospinal mechanisms in MS that map to clinical status. Delayed and longer ipsilateral silent period (a measure of transcallosal inhibition; the influence of one brain hemisphere’s activity over the other), longer cortical silent period (suggestive of greater corticospinal inhibition via GABA) and higher resting motor threshold (lower corticospinal excitability) most strongly related to clinical outcomes, especially when measured in the hemisphere corresponding to the weaker hand. Greater interhemispheric asymmetry (imbalance between hemispheres) correlated with poorer performance in the greatest number of clinical outcomes. We also show, not surprisingly, that TMS variables related more strongly to motor outcomes than non-motor outcomes. As it was validated in a large sample of patients with varying severities of central nervous system dysfunction, the protocol described herein can be used by investigators and clinicians alike to investigate the role of TMS as a biomarker in MS and other central nervous system disorders." @default.
- W3138648420 created "2021-03-29" @default.
- W3138648420 creator A5021135448 @default.
- W3138648420 creator A5048719144 @default.
- W3138648420 creator A5059429269 @default.
- W3138648420 creator A5071157557 @default.
- W3138648420 date "2021-03-17" @default.
- W3138648420 modified "2023-10-16" @default.
- W3138648420 title "Probing the Brain–Body Connection Using Transcranial Magnetic Stimulation (TMS): Validating a Promising Tool to Provide Biomarkers of Neuroplasticity and Central Nervous System Function" @default.
- W3138648420 cites W1547906203 @default.
- W3138648420 cites W1579457863 @default.
- W3138648420 cites W1741641790 @default.
- W3138648420 cites W1750926410 @default.
- W3138648420 cites W1771605475 @default.
- W3138648420 cites W1787731127 @default.
- W3138648420 cites W1852401591 @default.
- W3138648420 cites W1885957966 @default.
- W3138648420 cites W1965131444 @default.
- W3138648420 cites W1965319675 @default.
- W3138648420 cites W1967525341 @default.
- W3138648420 cites W1969666539 @default.
- W3138648420 cites W1973279678 @default.
- W3138648420 cites W1976353274 @default.
- W3138648420 cites W1980096322 @default.
- W3138648420 cites W1981457167 @default.
- W3138648420 cites W1983351242 @default.
- W3138648420 cites W1986110204 @default.
- W3138648420 cites W1990040006 @default.
- W3138648420 cites W1990185370 @default.
- W3138648420 cites W1991660386 @default.
- W3138648420 cites W1991711453 @default.
- W3138648420 cites W1991724800 @default.
- W3138648420 cites W1991952911 @default.
- W3138648420 cites W1992513810 @default.
- W3138648420 cites W1999110803 @default.
- W3138648420 cites W1999323085 @default.
- W3138648420 cites W2000446035 @default.
- W3138648420 cites W2007326167 @default.
- W3138648420 cites W2012460194 @default.
- W3138648420 cites W2013234597 @default.
- W3138648420 cites W2016839376 @default.
- W3138648420 cites W2018278032 @default.
- W3138648420 cites W2020745232 @default.
- W3138648420 cites W2025036175 @default.
- W3138648420 cites W2027839244 @default.
- W3138648420 cites W2030216368 @default.
- W3138648420 cites W2037889723 @default.
- W3138648420 cites W2039961324 @default.
- W3138648420 cites W2040943812 @default.
- W3138648420 cites W2041294159 @default.
- W3138648420 cites W2042676202 @default.
- W3138648420 cites W2042777359 @default.
- W3138648420 cites W2044124598 @default.
- W3138648420 cites W2044565695 @default.
- W3138648420 cites W2047175447 @default.
- W3138648420 cites W2047846607 @default.
- W3138648420 cites W2052676701 @default.
- W3138648420 cites W2054275233 @default.
- W3138648420 cites W2056881813 @default.
- W3138648420 cites W2057994890 @default.
- W3138648420 cites W2065159535 @default.
- W3138648420 cites W2065173611 @default.
- W3138648420 cites W2065447898 @default.
- W3138648420 cites W2066439376 @default.
- W3138648420 cites W2076074786 @default.
- W3138648420 cites W2078355922 @default.
- W3138648420 cites W2080448698 @default.
- W3138648420 cites W2084744928 @default.
- W3138648420 cites W2086016692 @default.
- W3138648420 cites W2091537113 @default.
- W3138648420 cites W2096715579 @default.
- W3138648420 cites W2099631417 @default.
- W3138648420 cites W2112165124 @default.
- W3138648420 cites W2119411157 @default.
- W3138648420 cites W2119412335 @default.
- W3138648420 cites W2119526403 @default.
- W3138648420 cites W2119714088 @default.
- W3138648420 cites W2122308507 @default.
- W3138648420 cites W2123359871 @default.
- W3138648420 cites W2123430619 @default.
- W3138648420 cites W2125769302 @default.
- W3138648420 cites W2126597767 @default.
- W3138648420 cites W2135311654 @default.
- W3138648420 cites W2137841176 @default.
- W3138648420 cites W2139293151 @default.
- W3138648420 cites W2140358254 @default.
- W3138648420 cites W2141796362 @default.
- W3138648420 cites W2142577589 @default.
- W3138648420 cites W2145481931 @default.
- W3138648420 cites W2145593481 @default.
- W3138648420 cites W2146051854 @default.
- W3138648420 cites W2149900811 @default.
- W3138648420 cites W2156092714 @default.
- W3138648420 cites W2158937646 @default.
- W3138648420 cites W2160810016 @default.
- W3138648420 cites W2167015445 @default.
- W3138648420 cites W2169496098 @default.
- W3138648420 cites W2173315418 @default.