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• W3138684152 abstract "Purpose To assess patterns of use of antiseizure medications (ASMs) and to compare the safety of generic versus branded formulations in terms of admission to hospital or to emergency department (ED). Methods We conducted a drug utilization study with a propensity score-matched design using the administrative databases of the Italian Tuscany region. New users of ASMs during 2015 with no history of neoplasia were considered and their first prescription was classified as: available only as branded (only-B-ASM); branded with generic available (B-ASM); and generic (G-ASM). Patients with G-ASM first prescription were matched with four patients with B-ASM prescription. Participants were followed up for one year or until the date of death or diagnosis of neoplasia. Cox regression models were fitted to estimate the risk of admission to hospital or ED. Results We identified 36,601 ASM new-users, including 2094 (6.4%) with only-B-ASM as first prescription, 24,588 (74.9%) with B-ASM, and 5788 (17.6%) with G-ASM. We found no differences in the risk of admission to hospital or ED (Hazard Ratio (HR), 0.92; 95% Confidence Interval (CI), 0.85–1.02) among users of generic ASMs compared to those using branded ASMs. Conclusions In our study population, generic ASMs were used less than branded ones. The similarity in the safety of branded and generic formulations suggests that generic ASMs could be the preferred formulation in current clinical practice resulting in a substantial decrease in the cost of treatment." @default.
• W3138684152 created "2021-03-29" @default.
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• W3138684152 date "2021-04-01" @default.
• W3138684152 modified "2023-09-24" @default.
• W3138684152 title "Use of antiseizure medications and safety of branded versus generic formulations: A comparative study on Tuscan administrative databases" @default.
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• W3138684152 doi "https://doi.org/10.1016/j.yebeh.2021.107876" @default.
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