FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138690800> ?p ?o ?g. }

• W3138690800 abstract "Abstract Background Multiple Sclerosis (MS) is a potentially devastating autoimmune neurological disorder, which characteristically induces demyelination of white matter in the brain and spinal cord. Methods In this study, three characteristics of the central nervous system (CNS) immune microenvironment occurring during MS onset were explored; immune cell proportion alteration, differential gene expression profile, and related pathways. The raw data of two independent datasets were obtained from the ArrayExpress database; E-MTAB-69, which was used as a derivation cohort, and E-MTAB-2374 which was used as a validation cohort. Differentially expressed genes (DEGs) were identified by the false discovery rate (FDR) value of < 0.05 and |log2 (Fold Change)|> 1, for further analysis. Then, functional enrichment analyses were performed to explore the pathways associated with MS onset. The gene expression profiles were analyzed using CIBERSORT to identify the immune type alterations involved in MS disease. Results After verification, the proportion of five types of immune cells (plasma cells, monocytes, macrophage M2, neutrophils and eosinophils) in cerebrospinal fluid (CSF) were revealed to be significantly altered in MS cases compared to the control group. Thus, the complement and coagulation cascades and the systemic lupus erythematosus (SLE) pathways may play critical roles in MS. We identified NLRP3, LILRB2, C1QB, CD86, C1QA, CSF1R, IL1B and TLR2 as eight core genes correlated with MS. Conclusions Our study identified the change in the CNS immune microenvironment of MS cases by analysis of the in silico data using CIBERSORT. Our data may assist in providing directions for further research as to the molecular mechanisms of MS and provide future potential therapeutic targets in treatment." @default.
• W3138690800 created "2021-03-29" @default.
• W3138690800 creator A5009074414 @default.
• W3138690800 creator A5048038908 @default.
• W3138690800 creator A5055517335 @default.
• W3138690800 creator A5055823098 @default.
• W3138690800 creator A5091419335 @default.
• W3138690800 date "2021-03-25" @default.
• W3138690800 modified "2023-10-18" @default.
• W3138690800 title "Cerebrospinal fluid cells immune landscape in multiple sclerosis" @default.
• W3138690800 cites W1983093750 @default.
• W3138690800 cites W1985987855 @default.
• W3138690800 cites W1987762357 @default.
• W3138690800 cites W1990538908 @default.
• W3138690800 cites W1993459259 @default.
• W3138690800 cites W2023018762 @default.
• W3138690800 cites W2036469393 @default.
• W3138690800 cites W2041482011 @default.
• W3138690800 cites W2049193169 @default.
• W3138690800 cites W2065999598 @default.
• W3138690800 cites W2077700370 @default.
• W3138690800 cites W2077702475 @default.
• W3138690800 cites W2079336414 @default.
• W3138690800 cites W2093700729 @default.
• W3138690800 cites W2111604834 @default.
• W3138690800 cites W2119260058 @default.
• W3138690800 cites W2156600899 @default.
• W3138690800 cites W2159707944 @default.
• W3138690800 cites W2163967436 @default.
• W3138690800 cites W2280880893 @default.
• W3138690800 cites W2463823726 @default.
• W3138690800 cites W2565183424 @default.
• W3138690800 cites W2618005361 @default.
• W3138690800 cites W2735193465 @default.
• W3138690800 cites W2736362590 @default.
• W3138690800 cites W2789900283 @default.
• W3138690800 cites W2884610214 @default.
• W3138690800 cites W2942610007 @default.
• W3138690800 cites W2952001873 @default.
• W3138690800 cites W2957111643 @default.
• W3138690800 cites W2964805603 @default.
• W3138690800 cites W2980198451 @default.
• W3138690800 cites W2986142969 @default.
• W3138690800 cites W2987851044 @default.
• W3138690800 cites W2995585740 @default.
• W3138690800 cites W3005889306 @default.
• W3138690800 cites W3009516645 @default.
• W3138690800 cites W3015703032 @default.
• W3138690800 cites W3022632841 @default.
• W3138690800 cites W3037256473 @default.
• W3138690800 cites W3037726491 @default.
• W3138690800 cites W3048887029 @default.
• W3138690800 cites W3082309784 @default.
• W3138690800 cites W3082437287 @default.
• W3138690800 cites W3083456037 @default.
• W3138690800 cites W3085697892 @default.
• W3138690800 cites W3092663425 @default.
• W3138690800 cites W3093751863 @default.
• W3138690800 cites W3097076948 @default.
• W3138690800 cites W3110149087 @default.
• W3138690800 cites W3110333651 @default.
• W3138690800 cites W3111703171 @default.
• W3138690800 cites W3127355606 @default.
• W3138690800 doi "https://doi.org/10.1186/s12967-021-02804-7" @default.
• W3138690800 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7995713" @default.
• W3138690800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33766068" @default.
• W3138690800 hasPublicationYear "2021" @default.
• W3138690800 type Work @default.
• W3138690800 sameAs 3138690800 @default.
• W3138690800 citedByCount "11" @default.
• W3138690800 countsByYear W31386908002021 @default.
• W3138690800 countsByYear W31386908002022 @default.
• W3138690800 countsByYear W31386908002023 @default.
• W3138690800 crossrefType "journal-article" @default.
• W3138690800 hasAuthorship W3138690800A5009074414 @default.
• W3138690800 hasAuthorship W3138690800A5048038908 @default.
• W3138690800 hasAuthorship W3138690800A5055517335 @default.
• W3138690800 hasAuthorship W3138690800A5055823098 @default.
• W3138690800 hasAuthorship W3138690800A5091419335 @default.
• W3138690800 hasBestOaLocation W31386908001 @default.
• W3138690800 hasConcept C169760540 @default.
• W3138690800 hasConcept C203014093 @default.
• W3138690800 hasConcept C2779651940 @default.
• W3138690800 hasConcept C2780640218 @default.
• W3138690800 hasConcept C71924100 @default.
• W3138690800 hasConcept C86803240 @default.
• W3138690800 hasConcept C8891405 @default.
• W3138690800 hasConceptScore W3138690800C169760540 @default.
• W3138690800 hasConceptScore W3138690800C203014093 @default.
• W3138690800 hasConceptScore W3138690800C2779651940 @default.
• W3138690800 hasConceptScore W3138690800C2780640218 @default.
• W3138690800 hasConceptScore W3138690800C71924100 @default.
• W3138690800 hasConceptScore W3138690800C86803240 @default.
• W3138690800 hasConceptScore W3138690800C8891405 @default.
• W3138690800 hasFunder F4320321001 @default.
• W3138690800 hasFunder F4320327473 @default.
• W3138690800 hasIssue "1" @default.
• W3138690800 hasLocation W31386908001 @default.
• W3138690800 hasLocation W31386908002 @default.
• W3138690800 hasOpenAccess W3138690800 @default.

• next