Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138705451> ?p ?o ?g. }
- W3138705451 endingPage "192" @default.
- W3138705451 startingPage "180" @default.
- W3138705451 abstract "Fucoidan is a sulfated polysaccharide obtained from marine algae and known for various pharmacological activities. In this study, we investigated the effect of Fucoidan on cell viability, redox balance, cytoskeletal component F-actin, HDAC inhibition, autophagy, and senescence phenomenon in human cervical cancer HeLa cell line in comparison to positive control suberoylanilide hydroxamic acid by flow cytometry, fluorescence microscopy, and western blotting. Our observations revealed that Fucoidan exposure induces cytotoxicity in HeLa cells via ROS and mitochondrial superoxide generation and loss of ATP. Colorimetrical studies suggested that Fucoidan impairs the function of HDAC expression. Fucoidan treatment also contributes to the change in the granularity of cells, senescence-associated heterochromatin foci formation that leads to senescence in HeLa cells. Moreover, we visualize that Fucoidan exhibits autophagosomes formation with monodansylcadaverine, and flow cytometry analysis by acridine orange further substantiates that Fucoidan triggers autophagy in HeLa cells. Additionally, the changes in the expression of proteins p21, p16, BECN1, and HDAC1 were seen as markers of senescence, autophagy, and HDAC inhibition by FACS and immunoblotting. Molecular docking study validates Fucoidan–HDAC1 association in corroboration with the experimental data. Collectively, these mechanistic studies demonstrated that Fucoidan could be a therapeutic molecule for targeting HDACs in cervical cancer." @default.
- W3138705451 created "2021-03-29" @default.
- W3138705451 creator A5056320031 @default.
- W3138705451 creator A5069157461 @default.
- W3138705451 creator A5084972369 @default.
- W3138705451 date "2021-06-01" @default.
- W3138705451 modified "2023-09-23" @default.
- W3138705451 title "Fucoidan induces ROS-dependent epigenetic modulation in cervical cancer HeLa cell" @default.
- W3138705451 cites W1141584201 @default.
- W3138705451 cites W1518755079 @default.
- W3138705451 cites W1524263391 @default.
- W3138705451 cites W1978212345 @default.
- W3138705451 cites W1978664410 @default.
- W3138705451 cites W1987249631 @default.
- W3138705451 cites W1988249582 @default.
- W3138705451 cites W1991910557 @default.
- W3138705451 cites W2001372725 @default.
- W3138705451 cites W2002617822 @default.
- W3138705451 cites W2003221870 @default.
- W3138705451 cites W2027171343 @default.
- W3138705451 cites W2031836717 @default.
- W3138705451 cites W2033885016 @default.
- W3138705451 cites W2037864697 @default.
- W3138705451 cites W2046005246 @default.
- W3138705451 cites W2050748595 @default.
- W3138705451 cites W2055193642 @default.
- W3138705451 cites W2059450077 @default.
- W3138705451 cites W2066264051 @default.
- W3138705451 cites W2066503677 @default.
- W3138705451 cites W2071254597 @default.
- W3138705451 cites W2079355772 @default.
- W3138705451 cites W2084249775 @default.
- W3138705451 cites W2086790402 @default.
- W3138705451 cites W2092242450 @default.
- W3138705451 cites W2096308078 @default.
- W3138705451 cites W2106506963 @default.
- W3138705451 cites W2107926413 @default.
- W3138705451 cites W2115788076 @default.
- W3138705451 cites W2119316269 @default.
- W3138705451 cites W2143894420 @default.
- W3138705451 cites W2144002661 @default.
- W3138705451 cites W2144110273 @default.
- W3138705451 cites W2144362290 @default.
- W3138705451 cites W2146935613 @default.
- W3138705451 cites W2150671144 @default.
- W3138705451 cites W2159675211 @default.
- W3138705451 cites W2160655220 @default.
- W3138705451 cites W2181076115 @default.
- W3138705451 cites W2267737556 @default.
- W3138705451 cites W2292271657 @default.
- W3138705451 cites W2340630159 @default.
- W3138705451 cites W2343307939 @default.
- W3138705451 cites W2350256796 @default.
- W3138705451 cites W2418952024 @default.
- W3138705451 cites W2461836249 @default.
- W3138705451 cites W2505470033 @default.
- W3138705451 cites W2518499518 @default.
- W3138705451 cites W2529723167 @default.
- W3138705451 cites W2563041420 @default.
- W3138705451 cites W2775175656 @default.
- W3138705451 cites W2888936354 @default.
- W3138705451 cites W2889646458 @default.
- W3138705451 cites W2900863907 @default.
- W3138705451 cites W2925001344 @default.
- W3138705451 cites W2967224921 @default.
- W3138705451 cites W2969453984 @default.
- W3138705451 cites W2979841778 @default.
- W3138705451 cites W2994247988 @default.
- W3138705451 cites W2998205994 @default.
- W3138705451 cites W3009972534 @default.
- W3138705451 cites W3088953284 @default.
- W3138705451 doi "https://doi.org/10.1016/j.ijbiomac.2021.03.110" @default.
- W3138705451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33771548" @default.
- W3138705451 hasPublicationYear "2021" @default.
- W3138705451 type Work @default.
- W3138705451 sameAs 3138705451 @default.
- W3138705451 citedByCount "15" @default.
- W3138705451 countsByYear W31387054512021 @default.
- W3138705451 countsByYear W31387054512022 @default.
- W3138705451 countsByYear W31387054512023 @default.
- W3138705451 crossrefType "journal-article" @default.
- W3138705451 hasAuthorship W3138705451A5056320031 @default.
- W3138705451 hasAuthorship W3138705451A5069157461 @default.
- W3138705451 hasAuthorship W3138705451A5084972369 @default.
- W3138705451 hasConcept C100817775 @default.
- W3138705451 hasConcept C137738243 @default.
- W3138705451 hasConcept C1491633281 @default.
- W3138705451 hasConcept C153911025 @default.
- W3138705451 hasConcept C185592680 @default.
- W3138705451 hasConcept C2775909754 @default.
- W3138705451 hasConcept C2777366897 @default.
- W3138705451 hasConcept C53227056 @default.
- W3138705451 hasConcept C553184892 @default.
- W3138705451 hasConcept C55493867 @default.
- W3138705451 hasConcept C86803240 @default.
- W3138705451 hasConcept C95444343 @default.
- W3138705451 hasConceptScore W3138705451C100817775 @default.
- W3138705451 hasConceptScore W3138705451C137738243 @default.