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- W3138719466 abstract "Immune systems respond to “non-self” molecules termed microbe-associated molecular patterns (MAMPs). Microbial genes encoding MAMPs have adaptive functions and are thus evolutionarily conserved. In the presence of a host, these genes are maladaptive and drive antagonistic pleiotropy (AP) because they promote microbe elimination by activating immune responses. The role AP plays in balancing the functionality of MAMP-coding genes against their immunogenicity is unknown. To address this, we focused on an epitope of flagellin that triggers antibacterial immunity in plants. Flagellin is conserved because it enables motility. Here, we decode the immunogenic and motility profiles of this flagellin epitope and determine the spectrum of amino acid mutations that drives AP. We discover two synthetic mutational tracks that undermine the detection activities of a plant flagellin receptor. These tracks generate epitopes with either antagonist or weaker agonist activities. Finally, we find signatures of these tracks layered atop each other in natural Pseudomonads." @default.
- W3138719466 created "2021-03-29" @default.
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- W3138719466 date "2021-04-01" @default.
- W3138719466 modified "2023-10-16" @default.
- W3138719466 title "Signatures of antagonistic pleiotropy in a bacterial flagellin epitope" @default.
- W3138719466 cites W1561589165 @default.
- W3138719466 cites W1826812957 @default.
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- W3138719466 cites W1971439989 @default.
- W3138719466 cites W1972449088 @default.
- W3138719466 cites W1979129889 @default.
- W3138719466 cites W1986780986 @default.
- W3138719466 cites W1994602890 @default.
- W3138719466 cites W1996935154 @default.
- W3138719466 cites W1998198773 @default.
- W3138719466 cites W2007619416 @default.
- W3138719466 cites W2018635688 @default.
- W3138719466 cites W2026884617 @default.
- W3138719466 cites W2027364010 @default.
- W3138719466 cites W2036917159 @default.
- W3138719466 cites W2038463428 @default.
- W3138719466 cites W2039466444 @default.
- W3138719466 cites W2040537350 @default.
- W3138719466 cites W2040975718 @default.
- W3138719466 cites W2041935855 @default.
- W3138719466 cites W2044757050 @default.
- W3138719466 cites W2058448508 @default.
- W3138719466 cites W2059336476 @default.
- W3138719466 cites W2061085465 @default.
- W3138719466 cites W2062018285 @default.
- W3138719466 cites W2062893362 @default.
- W3138719466 cites W2071174017 @default.
- W3138719466 cites W2073376866 @default.
- W3138719466 cites W2074044150 @default.
- W3138719466 cites W2077276598 @default.
- W3138719466 cites W2085801947 @default.
- W3138719466 cites W2090640877 @default.
- W3138719466 cites W2098139480 @default.
- W3138719466 cites W2099540110 @default.
- W3138719466 cites W2100886853 @default.
- W3138719466 cites W2102896143 @default.
- W3138719466 cites W2103556966 @default.
- W3138719466 cites W2110777390 @default.
- W3138719466 cites W2112242180 @default.
- W3138719466 cites W2115246376 @default.
- W3138719466 cites W2115888213 @default.
- W3138719466 cites W2119212891 @default.
- W3138719466 cites W2120056890 @default.
- W3138719466 cites W2121978187 @default.
- W3138719466 cites W2128974608 @default.
- W3138719466 cites W2129789442 @default.
- W3138719466 cites W2132926880 @default.
- W3138719466 cites W2133425351 @default.
- W3138719466 cites W2137003603 @default.
- W3138719466 cites W2148941537 @default.
- W3138719466 cites W2149863714 @default.
- W3138719466 cites W2153819533 @default.
- W3138719466 cites W2158266834 @default.
- W3138719466 cites W2167210281 @default.
- W3138719466 cites W2167279371 @default.
- W3138719466 cites W2168873194 @default.
- W3138719466 cites W2179324586 @default.
- W3138719466 cites W2181192066 @default.
- W3138719466 cites W22308802 @default.
- W3138719466 cites W2281992160 @default.
- W3138719466 cites W2289510404 @default.
- W3138719466 cites W2311203695 @default.
- W3138719466 cites W2346787980 @default.
- W3138719466 cites W2396522900 @default.
- W3138719466 cites W2419574648 @default.
- W3138719466 cites W2466001904 @default.
- W3138719466 cites W2513189807 @default.
- W3138719466 cites W2528346093 @default.
- W3138719466 cites W2556869668 @default.
- W3138719466 cites W2582295603 @default.
- W3138719466 cites W2586147377 @default.