Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138749225> ?p ?o ?g. }
- W3138749225 endingPage "354" @default.
- W3138749225 startingPage "344" @default.
- W3138749225 abstract "In the current study, we established a novel murine ischemic brain damage model using a photochemical reaction to evaluate the recovery of neurological dysfunction and brain repair reactions. In this model, reproducible damage was induced in the frontal lobe of the cortex, which was accompanied by neurological dysfunction. Sequential changes in damage size, microglial accumulation, astrocyte activation, and neurological dysfunction were studied in C57BL/6J and BALB/c mouse strains. Although the initial size of damage was comparable in both strains, the extent of damage was later reduced to a greater extent in C57BL/6J mice than that in BALB/c mice. In addition, C57BL/6J mice showed later edema clearance until day 7, less microglial accumulation, and relatively more astrocyte activation on day 7. Neurologic dysfunction was evaluated by three behavioral tests: the von Frey test, the balance beam test, and the tail suspension test. The behavioral abnormalities evaluated by these tests were remarkable following the induction of damage and recovered by day 21 in both strains. However, the abnormalities were more prominent and the recovery was later in C57BL/6J mice. These findings demonstrate that our novel ischemic stroke model is useful for evaluating brain repair reactions and the recovery of neurological dysfunction in mice with different genetic backgrounds. In addition, we found that both the brain repair reactions and the recovery of neurological dysfunction after comparable ischemic brain damage varied between strains; in that, they both occurred later in C57BL/6J mice." @default.
- W3138749225 created "2021-03-29" @default.
- W3138749225 creator A5003564953 @default.
- W3138749225 creator A5025926501 @default.
- W3138749225 creator A5033388551 @default.
- W3138749225 creator A5058982550 @default.
- W3138749225 creator A5066435159 @default.
- W3138749225 creator A5073588329 @default.
- W3138749225 creator A5074442133 @default.
- W3138749225 creator A5088804804 @default.
- W3138749225 date "2021-01-01" @default.
- W3138749225 modified "2023-09-26" @default.
- W3138749225 title "Repair of brain damage size and recovery of neurological dysfunction after ischemic stroke are different between strains in mice: evaluation using a novel ischemic stroke model" @default.
- W3138749225 cites W1965995070 @default.
- W3138749225 cites W2017756927 @default.
- W3138749225 cites W2022593257 @default.
- W3138749225 cites W2023419933 @default.
- W3138749225 cites W2027713233 @default.
- W3138749225 cites W2027937434 @default.
- W3138749225 cites W2032364598 @default.
- W3138749225 cites W2037121520 @default.
- W3138749225 cites W2059982861 @default.
- W3138749225 cites W2077379332 @default.
- W3138749225 cites W2077850837 @default.
- W3138749225 cites W2088073775 @default.
- W3138749225 cites W2094728278 @default.
- W3138749225 cites W2095885953 @default.
- W3138749225 cites W2104968232 @default.
- W3138749225 cites W2119745487 @default.
- W3138749225 cites W2143624335 @default.
- W3138749225 cites W2166138570 @default.
- W3138749225 cites W2167620056 @default.
- W3138749225 cites W2328217243 @default.
- W3138749225 cites W2504058217 @default.
- W3138749225 cites W2709801556 @default.
- W3138749225 cites W2883678860 @default.
- W3138749225 doi "https://doi.org/10.1538/expanim.20-0182" @default.
- W3138749225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8390305" @default.
- W3138749225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33731549" @default.
- W3138749225 hasPublicationYear "2021" @default.
- W3138749225 type Work @default.
- W3138749225 sameAs 3138749225 @default.
- W3138749225 citedByCount "2" @default.
- W3138749225 countsByYear W31387492252022 @default.
- W3138749225 countsByYear W31387492252023 @default.
- W3138749225 crossrefType "journal-article" @default.
- W3138749225 hasAuthorship W3138749225A5003564953 @default.
- W3138749225 hasAuthorship W3138749225A5025926501 @default.
- W3138749225 hasAuthorship W3138749225A5033388551 @default.
- W3138749225 hasAuthorship W3138749225A5058982550 @default.
- W3138749225 hasAuthorship W3138749225A5066435159 @default.
- W3138749225 hasAuthorship W3138749225A5073588329 @default.
- W3138749225 hasAuthorship W3138749225A5074442133 @default.
- W3138749225 hasAuthorship W3138749225A5088804804 @default.
- W3138749225 hasBestOaLocation W31387492251 @default.
- W3138749225 hasConcept C126322002 @default.
- W3138749225 hasConcept C127413603 @default.
- W3138749225 hasConcept C142724271 @default.
- W3138749225 hasConcept C169760540 @default.
- W3138749225 hasConcept C2777348757 @default.
- W3138749225 hasConcept C2777542381 @default.
- W3138749225 hasConcept C2780645631 @default.
- W3138749225 hasConcept C2781458332 @default.
- W3138749225 hasConcept C42219234 @default.
- W3138749225 hasConcept C529278444 @default.
- W3138749225 hasConcept C71924100 @default.
- W3138749225 hasConcept C78519656 @default.
- W3138749225 hasConcept C86803240 @default.
- W3138749225 hasConceptScore W3138749225C126322002 @default.
- W3138749225 hasConceptScore W3138749225C127413603 @default.
- W3138749225 hasConceptScore W3138749225C142724271 @default.
- W3138749225 hasConceptScore W3138749225C169760540 @default.
- W3138749225 hasConceptScore W3138749225C2777348757 @default.
- W3138749225 hasConceptScore W3138749225C2777542381 @default.
- W3138749225 hasConceptScore W3138749225C2780645631 @default.
- W3138749225 hasConceptScore W3138749225C2781458332 @default.
- W3138749225 hasConceptScore W3138749225C42219234 @default.
- W3138749225 hasConceptScore W3138749225C529278444 @default.
- W3138749225 hasConceptScore W3138749225C71924100 @default.
- W3138749225 hasConceptScore W3138749225C78519656 @default.
- W3138749225 hasConceptScore W3138749225C86803240 @default.
- W3138749225 hasIssue "3" @default.
- W3138749225 hasLocation W31387492251 @default.
- W3138749225 hasLocation W31387492252 @default.
- W3138749225 hasOpenAccess W3138749225 @default.
- W3138749225 hasPrimaryLocation W31387492251 @default.
- W3138749225 hasRelatedWork W15165663 @default.
- W3138749225 hasRelatedWork W2011081555 @default.
- W3138749225 hasRelatedWork W2049567231 @default.
- W3138749225 hasRelatedWork W2101205829 @default.
- W3138749225 hasRelatedWork W2286168122 @default.
- W3138749225 hasRelatedWork W2356381647 @default.
- W3138749225 hasRelatedWork W2549135832 @default.
- W3138749225 hasRelatedWork W2908110468 @default.
- W3138749225 hasRelatedWork W2971470218 @default.
- W3138749225 hasRelatedWork W3177902858 @default.
- W3138749225 hasVolume "70" @default.
- W3138749225 isParatext "false" @default.