FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138792246> ?p ?o ?g. }

• W3138792246 abstract "The genus Streptococcus encompasses a large bacterial taxon that commonly colonizes mucosal surfaces of vertebrates and is capable of disease etiologies originating from diverse body sites, including the respiratory, digestive, and reproductive tracts. Identifying new modes of treating infections is of increasing importance, as antibiotic resistance has escalated. Streptococcus mutans is an important opportunistic pathogen that is an agent of dental caries and is capable of systemic diseases such as endocarditis. As such, understanding how it regulates virulence and competes in the oral niche is a priority in developing strategies to defend from these pathogens. We determined that S. mutans UA159 possesses a bona fide short hydrophobic peptide (SHP)/Rgg quorum-sensing system that regulates a specialized biosynthetic operon featuring a radical-SAM (S-adenosyl-l-methionine) (RaS) enzyme and produces a ribosomally synthesized and posttranslationally modified peptide (RiPP). The pairing of SHP/Rgg regulatory systems with RaS biosynthetic operons is conserved across streptococci, and a locus similar to that in S. mutans is found in Streptococcus ferus, an oral streptococcus isolated from wild rats. We identified the RaS-RiPP product from this operon and solved its structure using a combination of analytical methods; we term these RiPPs tryglysin A and B for the unusual Trp-Gly-Lys linkage. We report that tryglysins specifically inhibit the growth of other streptococci, but not other Gram-positive bacteria such as Enterococcus faecalis or Lactococcus lactis We predict that tryglysin is produced by S. mutans in its oral niche, thus inhibiting the growth of competing species, including several medically relevant streptococci.IMPORTANCE Bacteria interact and compete with a large community of organisms in their natural environment. Streptococcus mutans is one such organism, and it is an important member of the oral microbiota. We found that S. mutans uses a quorum-sensing system to regulate production of a novel posttranslationally modified peptide capable of inhibiting growth of several streptococcal species. We find inhibitory properties of a similar peptide produced by S. ferus and predict that these peptides play a role in interspecies competition in the oral niche." @default.
• W3138792246 created "2021-03-29" @default.
• W3138792246 creator A5005549043 @default.
• W3138792246 creator A5025258635 @default.
• W3138792246 creator A5040986100 @default.
• W3138792246 creator A5052902179 @default.
• W3138792246 creator A5082921592 @default.
• W3138792246 creator A5086333002 @default.
• W3138792246 creator A5090229420 @default.
• W3138792246 date "2021-04-27" @default.
• W3138792246 modified "2023-10-12" @default.
• W3138792246 title "Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound" @default.
• W3138792246 cites W1733312454 @default.
• W3138792246 cites W1854736465 @default.
• W3138792246 cites W1871472387 @default.
• W3138792246 cites W1924538875 @default.
• W3138792246 cites W1977782657 @default.
• W3138792246 cites W1987144692 @default.
• W3138792246 cites W1992130716 @default.
• W3138792246 cites W1993158258 @default.
• W3138792246 cites W2024036417 @default.
• W3138792246 cites W2028670536 @default.
• W3138792246 cites W2029069567 @default.
• W3138792246 cites W2033205630 @default.
• W3138792246 cites W2050006541 @default.
• W3138792246 cites W2055043387 @default.
• W3138792246 cites W2061579546 @default.
• W3138792246 cites W2068521456 @default.
• W3138792246 cites W2071465566 @default.
• W3138792246 cites W2072535553 @default.
• W3138792246 cites W2077169747 @default.
• W3138792246 cites W2096008023 @default.
• W3138792246 cites W2096223900 @default.
• W3138792246 cites W2099540110 @default.
• W3138792246 cites W2102107256 @default.
• W3138792246 cites W2107277218 @default.
• W3138792246 cites W2107402575 @default.
• W3138792246 cites W2110621364 @default.
• W3138792246 cites W2111863350 @default.
• W3138792246 cites W2114104545 @default.
• W3138792246 cites W2115859783 @default.
• W3138792246 cites W2119610831 @default.
• W3138792246 cites W2125582698 @default.
• W3138792246 cites W2128301757 @default.
• W3138792246 cites W2130197000 @default.
• W3138792246 cites W2131226850 @default.
• W3138792246 cites W2131869707 @default.
• W3138792246 cites W2132868585 @default.
• W3138792246 cites W2133285842 @default.
• W3138792246 cites W2138207763 @default.
• W3138792246 cites W2138307476 @default.
• W3138792246 cites W2139222416 @default.
• W3138792246 cites W2140405224 @default.
• W3138792246 cites W2141015679 @default.
• W3138792246 cites W2141184808 @default.
• W3138792246 cites W2154519103 @default.
• W3138792246 cites W2155439177 @default.
• W3138792246 cites W2159340830 @default.
• W3138792246 cites W2159952824 @default.
• W3138792246 cites W2161245713 @default.
• W3138792246 cites W2167820176 @default.
• W3138792246 cites W2171158963 @default.
• W3138792246 cites W2171577160 @default.
• W3138792246 cites W2171622268 @default.
• W3138792246 cites W2365394358 @default.
• W3138792246 cites W2396643508 @default.
• W3138792246 cites W2406250479 @default.
• W3138792246 cites W2408351055 @default.
• W3138792246 cites W2558330600 @default.
• W3138792246 cites W2562009087 @default.
• W3138792246 cites W2592527354 @default.
• W3138792246 cites W2623959065 @default.
• W3138792246 cites W2754796511 @default.
• W3138792246 cites W2755025259 @default.
• W3138792246 cites W2756033011 @default.
• W3138792246 cites W2768059482 @default.
• W3138792246 cites W2770252239 @default.
• W3138792246 cites W2791562506 @default.
• W3138792246 cites W2791996700 @default.
• W3138792246 cites W2794743485 @default.
• W3138792246 cites W2799314805 @default.
• W3138792246 cites W2800838243 @default.
• W3138792246 cites W2896937938 @default.
• W3138792246 cites W2899986496 @default.
• W3138792246 cites W2902906807 @default.
• W3138792246 cites W2909792850 @default.
• W3138792246 cites W2910428070 @default.
• W3138792246 cites W2931314706 @default.
• W3138792246 cites W2938574745 @default.
• W3138792246 cites W2938620882 @default.
• W3138792246 cites W2951949542 @default.
• W3138792246 cites W2952845635 @default.
• W3138792246 cites W2952995076 @default.
• W3138792246 cites W2979849716 @default.
• W3138792246 cites W3006329125 @default.
• W3138792246 cites W3081460337 @default.
• W3138792246 cites W3083778496 @default.
• W3138792246 doi "https://doi.org/10.1128/mbio.02688-20" @default.
• W3138792246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8092268" @default.
• W3138792246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33727351" @default.

• next