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- W3138792431 abstract "Immune checkpoint inhibitors (ICIs) are major weapons in the modern era of anticancer therapy. Immune-related adverse events (irAEs) usually appear within the first three months of ICI treatment [ [1] Champiat S. Lambotte O. Barreau E. Belkhir R. Berdelou A. Carbonnel F. et al. Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper. Ann Oncol. 2016; 27: 559-574 Abstract Full Text Full Text PDF PubMed Scopus (509) Google Scholar ], but some have been reported up to one year after the introduction of ICIs and sometimes after the treatment has been stopped. A plateau in the survival curve is observable for patients treated with ICIs after the third year, which can be prolonged to 10 years for some [ [2] Schadendorf D. Hodi F.S. Robert C. Weber J.S. Margolin K. Hamid O. et al. Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma. J Clin Orthod. 2015; 33: 1889-1894 Google Scholar ]. A new category of patients is therefore emerging, that can be called ‘long-term survivors’ (LTS) [ [3] Topalian S.L. Hodi F.S. Brahmer J.R. Gettinger S.N. Smith D.C. McDermott D.F. et al. Five-year survival and correlates among patients with advanced melanoma, renal cell carcinoma, or non–small cell lung cancer treated with nivolumab. JAMA Oncol. 2019; 5: 1411-1420 Crossref PubMed Scopus (175) Google Scholar ]. The management of these patients is still unknown. The long-term follow-up for ICI-treated patients should consider new irAEs possibly occurring after treatment cessation and quality of life (Qol)." @default.
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- W3138792431 date "2021-05-01" @default.
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- W3138792431 title "Long-term impact of immunotherapy on quality of life of surviving patients: A multi-dimensional descriptive clinical study" @default.
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- W3138792431 doi "https://doi.org/10.1016/j.ejca.2021.02.018" @default.
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