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- W3138796525 abstract "Establishment of spermatogonia throughout the fetal and postnatal period is essential for production of spermatozoa and male fertility. Here, we established a protocol for in vitro reconstitution of human prospermatogonial specification whereby human primordial germ cell (PGC)-like cells (hPGCLCs) differentiated from human induced pluripotent stem cells were further induced into M-prospermatogonia-like cells (MLCs) and T1 prospermatogonia-like cells (T1LCs) using long-term cultured xenogeneic reconstituted testes. Single cell RNA-sequencing was used to delineate the lineage trajectory leading to T1LCs, which closely resemble human T1-prospermatogonia in vivo and exhibited gene expression related to spermatogenesis and diminished proliferation, a hallmark of quiescent T1 prospermatogonia. Notably, this system enabled us to visualize the dynamic and stage-specific regulation of transposable elements during human prospermatogonial specification. Together, our findings pave the way for understanding and reconstructing human male germline development in vitro." @default.
- W3138796525 created "2021-03-29" @default.
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- W3138796525 date "2020-01-01" @default.
- W3138796525 modified "2023-10-04" @default.
- W3138796525 title "Reconstitution of Prospermatogonial Specification <i>In vitro</i> from Human Induced Pluripotent Stem Cells" @default.
- W3138796525 doi "https://doi.org/10.2139/ssrn.3611046" @default.
- W3138796525 hasPublicationYear "2020" @default.
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