Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138796614> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W3138796614 abstract "The present analytical work is a unique method development and validation for the determination of dissolution of Eltrombopag using reverse phase high-performance liquid chromatography (HPLC) with isocratic elution technique. HPLC method for quantification of drug in dissolution samples of Eltrombopag tablet is developed and validated. About 0.5% polysorbate 80 in phosphate buffer of pH −6.8 is used as dissolution medium and paddle (USP-II) as apparatus at 50 rpm. The sample was withdrawn after 45 min. The developed HPLC method was used for quantitative estimation of drug release in dissolution samples of Eltrombopag tablet. Here, the stationary phase used was Xbridge C18 (50 mm × 4.6 mm × 5 μm), mobile phase was 25% ammonium formate and 75% acetonitrile. pH of the buffer solution was maintained at 3.0, flow rate 1.0 ml/min. Eluted material underwent for monitoring at the detector wavelength of 230 nm. Retention time for Eltrombopag was found to be 2.16 min; and linearity range was 3.516 µg/mL–131.862 µg/mL. The new method was evaluated according to the ICH guideline and as far as validation results are concern correlation coefficient value that was 1.0000 for the compound, percentage recovery 99.4%, and repeatability results relative standard deviation 0.6 for Eltrombopag. The developed HPLC method was found to be a simple and rapid one for regular analysis in professional laboratory." @default.
- W3138796614 created "2021-03-29" @default.
- W3138796614 creator A5009877614 @default.
- W3138796614 creator A5057756889 @default.
- W3138796614 creator A5059989809 @default.
- W3138796614 date "2020-12-15" @default.
- W3138796614 modified "2023-09-25" @default.
- W3138796614 title "Dissolution Method Validation with Reverse Phase Chromatographic Method for Determination of Eltrombopag Drug Release in Dissolution Samples of Tablets" @default.
- W3138796614 hasPublicationYear "2020" @default.
- W3138796614 type Work @default.
- W3138796614 sameAs 3138796614 @default.
- W3138796614 citedByCount "0" @default.
- W3138796614 crossrefType "posted-content" @default.
- W3138796614 hasAuthorship W3138796614A5009877614 @default.
- W3138796614 hasAuthorship W3138796614A5057756889 @default.
- W3138796614 hasAuthorship W3138796614A5059989809 @default.
- W3138796614 hasConcept C147789679 @default.
- W3138796614 hasConcept C154020017 @default.
- W3138796614 hasConcept C159654299 @default.
- W3138796614 hasConcept C179998833 @default.
- W3138796614 hasConcept C185592680 @default.
- W3138796614 hasConcept C203014093 @default.
- W3138796614 hasConcept C2780588981 @default.
- W3138796614 hasConcept C2993327898 @default.
- W3138796614 hasConcept C43617362 @default.
- W3138796614 hasConcept C73826308 @default.
- W3138796614 hasConcept C77281830 @default.
- W3138796614 hasConcept C86803240 @default.
- W3138796614 hasConcept C88380143 @default.
- W3138796614 hasConceptScore W3138796614C147789679 @default.
- W3138796614 hasConceptScore W3138796614C154020017 @default.
- W3138796614 hasConceptScore W3138796614C159654299 @default.
- W3138796614 hasConceptScore W3138796614C179998833 @default.
- W3138796614 hasConceptScore W3138796614C185592680 @default.
- W3138796614 hasConceptScore W3138796614C203014093 @default.
- W3138796614 hasConceptScore W3138796614C2780588981 @default.
- W3138796614 hasConceptScore W3138796614C2993327898 @default.
- W3138796614 hasConceptScore W3138796614C43617362 @default.
- W3138796614 hasConceptScore W3138796614C73826308 @default.
- W3138796614 hasConceptScore W3138796614C77281830 @default.
- W3138796614 hasConceptScore W3138796614C86803240 @default.
- W3138796614 hasConceptScore W3138796614C88380143 @default.
- W3138796614 hasLocation W31387966141 @default.
- W3138796614 hasOpenAccess W3138796614 @default.
- W3138796614 hasPrimaryLocation W31387966141 @default.
- W3138796614 hasRelatedWork W2001943506 @default.
- W3138796614 hasRelatedWork W2070004986 @default.
- W3138796614 hasRelatedWork W2072003196 @default.
- W3138796614 hasRelatedWork W2072897888 @default.
- W3138796614 hasRelatedWork W2167169519 @default.
- W3138796614 hasRelatedWork W2183275300 @default.
- W3138796614 hasRelatedWork W2188805377 @default.
- W3138796614 hasRelatedWork W2392298170 @default.
- W3138796614 hasRelatedWork W2556793891 @default.
- W3138796614 hasRelatedWork W2763251138 @default.
- W3138796614 hasRelatedWork W2787093804 @default.
- W3138796614 hasRelatedWork W3197051227 @default.
- W3138796614 hasRelatedWork W3205850250 @default.
- W3138796614 hasRelatedWork W2182464749 @default.
- W3138796614 hasRelatedWork W2182702290 @default.
- W3138796614 hasRelatedWork W2183803833 @default.
- W3138796614 hasRelatedWork W2185651178 @default.
- W3138796614 hasRelatedWork W2187768263 @default.
- W3138796614 hasRelatedWork W2603565344 @default.
- W3138796614 hasRelatedWork W2786556230 @default.
- W3138796614 isParatext "false" @default.
- W3138796614 isRetracted "false" @default.
- W3138796614 magId "3138796614" @default.
- W3138796614 workType "article" @default.