FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138804135> ?p ?o ?g. }

• W3138804135 endingPage "2512" @default.
• W3138804135 startingPage "2502" @default.
• W3138804135 abstract "G protein-coupled receptors (GPCRs) are membrane-bound proteins that are ubiquitously expressed in many cell types and take part in mediating multiple signaling pathways. GPCRs are dynamic proteins and exist in an equilibrium between an ensemble of conformational states such as inactive and fully active states. This dynamic nature of GPCRs is one of the factors that confers their basal activity even in the absence of any ligand-mediated activation. Ligands selectively bind and stabilize a subset of the conformations from the ensemble leading to a shift in the equilibrium toward the inactive or the active state depending on the nature of the ligand. This ligand-selective effect is achieved through allosteric communication between the ligand binding site and G protein or β-arrestin coupling site. Similarly, the G protein coupling to the receptor exerts the allosteric effect on the ligand binding region leading to increased binding affinity for agonists and decreased affinity for antagonists or inverse agonists. In this review, we enumerate the current state of our understanding of the mechanism of allosteric communication in GPCRs with a specific focus on the critical role of computational methods in delineating the residues involved in allosteric communication. Analyzing allosteric communication mechanism using molecular dynamics simulations has revealed (a) a structurally conserved mechanism of allosteric communication that regulates the G protein coupling, (b) a rational structure-based approach to designing selective ligands, and (c) an approach to designing allosteric GPCR mutants that are either ligand and G protein or β-arrestin selective." @default.
• W3138804135 created "2021-03-29" @default.
• W3138804135 creator A5019715172 @default.
• W3138804135 creator A5060670368 @default.
• W3138804135 creator A5080635161 @default.
• W3138804135 date "2021-04-01" @default.
• W3138804135 modified "2023-10-12" @default.
• W3138804135 title "Allosteric communication regulates ligand‐specific GPCR activity" @default.
• W3138804135 cites W1969591740 @default.
• W3138804135 cites W1973739813 @default.
• W3138804135 cites W1999976306 @default.
• W3138804135 cites W2000137866 @default.
• W3138804135 cites W2024620705 @default.
• W3138804135 cites W2038709562 @default.
• W3138804135 cites W2039241525 @default.
• W3138804135 cites W2043313133 @default.
• W3138804135 cites W2047119159 @default.
• W3138804135 cites W2067973462 @default.
• W3138804135 cites W2070354036 @default.
• W3138804135 cites W2075796864 @default.
• W3138804135 cites W2078108096 @default.
• W3138804135 cites W2078876572 @default.
• W3138804135 cites W2081833468 @default.
• W3138804135 cites W2084884919 @default.
• W3138804135 cites W2102459914 @default.
• W3138804135 cites W2112287740 @default.
• W3138804135 cites W2116803443 @default.
• W3138804135 cites W2156257459 @default.
• W3138804135 cites W2162109316 @default.
• W3138804135 cites W2257600479 @default.
• W3138804135 cites W2301716143 @default.
• W3138804135 cites W2335129184 @default.
• W3138804135 cites W2345966590 @default.
• W3138804135 cites W2399759053 @default.
• W3138804135 cites W2469309996 @default.
• W3138804135 cites W2474393700 @default.
• W3138804135 cites W2495252094 @default.
• W3138804135 cites W2516442526 @default.
• W3138804135 cites W2516773138 @default.
• W3138804135 cites W2528878255 @default.
• W3138804135 cites W2530696470 @default.
• W3138804135 cites W2536228565 @default.
• W3138804135 cites W2549537074 @default.
• W3138804135 cites W2560706187 @default.
• W3138804135 cites W2611100790 @default.
• W3138804135 cites W2624652951 @default.
• W3138804135 cites W2746860912 @default.
• W3138804135 cites W2748265524 @default.
• W3138804135 cites W2753735048 @default.
• W3138804135 cites W2766731343 @default.
• W3138804135 cites W2771868228 @default.
• W3138804135 cites W2784655325 @default.
• W3138804135 cites W2786348901 @default.
• W3138804135 cites W2791505431 @default.
• W3138804135 cites W2794209945 @default.
• W3138804135 cites W2796750185 @default.
• W3138804135 cites W2809222894 @default.
• W3138804135 cites W2809303314 @default.
• W3138804135 cites W2809529383 @default.
• W3138804135 cites W2810768392 @default.
• W3138804135 cites W2890537116 @default.
• W3138804135 cites W2890544573 @default.
• W3138804135 cites W2897600200 @default.
• W3138804135 cites W2900070330 @default.
• W3138804135 cites W2902049135 @default.
• W3138804135 cites W2910817182 @default.
• W3138804135 cites W2914322496 @default.
• W3138804135 cites W2928709393 @default.
• W3138804135 cites W2946834818 @default.
• W3138804135 cites W2950346042 @default.
• W3138804135 cites W2952431879 @default.
• W3138804135 cites W2965225396 @default.
• W3138804135 cites W2981484830 @default.
• W3138804135 cites W2991478808 @default.
• W3138804135 cites W3003635251 @default.
• W3138804135 cites W3006950105 @default.
• W3138804135 cites W3014501695 @default.
• W3138804135 cites W3016362743 @default.
• W3138804135 cites W3030533699 @default.
• W3138804135 cites W3032412335 @default.
• W3138804135 cites W3036711312 @default.
• W3138804135 cites W3039038596 @default.
• W3138804135 cites W3046878556 @default.
• W3138804135 cites W3082909526 @default.
• W3138804135 cites W3083892235 @default.
• W3138804135 cites W3092835062 @default.
• W3138804135 cites W3103582283 @default.
• W3138804135 cites W3110199116 @default.
• W3138804135 cites W3110321636 @default.
• W3138804135 cites W3112218391 @default.
• W3138804135 cites W3112926360 @default.
• W3138804135 cites W3115491766 @default.
• W3138804135 cites W3126132735 @default.
• W3138804135 cites W3135498947 @default.
• W3138804135 cites W4234946072 @default.
• W3138804135 cites W4242547712 @default.
• W3138804135 cites W837570822 @default.
• W3138804135 doi "https://doi.org/10.1111/febs.15826" @default.

• next