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• W3138805093 endingPage "3840" @default.
• W3138805093 startingPage "3826" @default.
• W3138805093 abstract "Abstract Restriction-modification (R-M) systems represent a first line of defense against invasive DNAs, such as bacteriophage DNAs, and are widespread among bacteria and archaea. By acquiring a Type II R-M system via horizontal gene transfer, the new hosts generally become more resistant to phage infection, through the action of a restriction endonuclease (REase), which cleaves DNA at or near specific sequences. A modification methyltransferase (MTase) serves to protect the host genome against its cognate REase activity. The production of R-M system components upon entering a new host cell must be finely tuned to confer protective methylation before the REase acts, to avoid host genome damage. Some type II R-M systems rely on a third component, the controller (C) protein, which is a transcription factor that regulates the production of REase and/or MTase. Previous studies have suggested C protein effects on the dynamics of expression of an R-M system during its establishment in a new host cell. Here, we directly examine these effects. By fluorescently labelling REase and MTase, we demonstrate that lack of a C protein reduces the delay of REase production, to the point of being simultaneous with, or even preceding, production of the MTase. Single molecule tracking suggests that a REase and a MTase employ different strategies for their target search within host cells, with the MTase spending much more time diffusing in proximity to the nucleoid than does the REase. This difference may partially ameliorate the toxic effects of premature REase expression." @default.
• W3138805093 created "2021-03-29" @default.
• W3138805093 creator A5016845473 @default.
• W3138805093 creator A5022481591 @default.
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• W3138805093 creator A5038689328 @default.
• W3138805093 creator A5041615611 @default.
• W3138805093 creator A5042389693 @default.
• W3138805093 creator A5063490186 @default.
• W3138805093 date "2021-03-21" @default.
• W3138805093 modified "2023-09-26" @default.
• W3138805093 title "Regulator-dependent temporal dynamics of a restriction-modification system's gene expression upon entering new host cells: single-cell and population studies" @default.
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