FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138820503> ?p ?o ?g. }

• W3138820503 endingPage "1336" @default.
• W3138820503 startingPage "1327" @default.
• W3138820503 abstract "The human macrophage galactose lectin (MGL) is an endocytic type II transmembrane receptor expressed on immature monocyte-derived dendritic cells and activated macrophages and plays a role in modulating the immune system in response to infections and cancer. MGL contains an extracellular calcium-dependent (C-type) carbohydrate recognition domain (CRD) that specifically binds terminal N-acetylgalactosamine glycan residues such as the Tn and sialyl-Tn antigens found on tumor cells, as well as other N- and O-glycans displayed on certain viruses and parasites. Even though the glycan specificity of MGL is known and several binding glycoproteins have been identified, the molecular basis for substrate recognition has remained elusive due to the lack of high-resolution structures. Here we present crystal structures of the MGL CRD at near endosomal pH and in several complexes, which reveal details of the interactions with the natural ligand, GalNAc, the cancer-associated Tn-Ser antigen, and a synthetic GalNAc mimetic ligand. Like the asialoglycoprotein receptor, additional calcium atoms are present and contribute to stabilization of the MGL CRD fold. The structure provides the molecular basis for preferential binding of N-acetylgalactosamine over galactose and prompted the re-evaluation of the binding modes previously proposed in solution. Saturation transfer difference nuclear magnetic resonance data acquired using the MGL CRD and interpreted using the crystal structure indicate a single binding mode for GalNAc in solution. Models of MGL1 and MGL2, the mouse homologues of MGL, explain how these proteins might recognize LewisX and GalNAc, respectively." @default.
• W3138820503 created "2021-03-29" @default.
• W3138820503 creator A5009089345 @default.
• W3138820503 creator A5017286913 @default.
• W3138820503 creator A5037336807 @default.
• W3138820503 creator A5057114335 @default.
• W3138820503 creator A5058559016 @default.
• W3138820503 creator A5063594309 @default.
• W3138820503 creator A5076449419 @default.
• W3138820503 creator A5077781498 @default.
• W3138820503 creator A5077818736 @default.
• W3138820503 creator A5078435865 @default.
• W3138820503 date "2021-03-16" @default.
• W3138820503 modified "2023-10-17" @default.
• W3138820503 title "Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen" @default.
• W3138820503 cites W1600675765 @default.
• W3138820503 cites W1964144818 @default.
• W3138820503 cites W1971835215 @default.
• W3138820503 cites W1983974025 @default.
• W3138820503 cites W1984716857 @default.
• W3138820503 cites W1986573181 @default.
• W3138820503 cites W2012286532 @default.
• W3138820503 cites W2025195614 @default.
• W3138820503 cites W2025723582 @default.
• W3138820503 cites W2034867322 @default.
• W3138820503 cites W2038840577 @default.
• W3138820503 cites W2049852043 @default.
• W3138820503 cites W2051336083 @default.
• W3138820503 cites W2053400250 @default.
• W3138820503 cites W2060106686 @default.
• W3138820503 cites W2071466250 @default.
• W3138820503 cites W2072348008 @default.
• W3138820503 cites W2076111323 @default.
• W3138820503 cites W2090890529 @default.
• W3138820503 cites W2098943363 @default.
• W3138820503 cites W2104341089 @default.
• W3138820503 cites W2108609481 @default.
• W3138820503 cites W2108921801 @default.
• W3138820503 cites W2112998064 @default.
• W3138820503 cites W2116375742 @default.
• W3138820503 cites W2129081766 @default.
• W3138820503 cites W2130479394 @default.
• W3138820503 cites W2138032601 @default.
• W3138820503 cites W2139406125 @default.
• W3138820503 cites W2144081223 @default.
• W3138820503 cites W2144288821 @default.
• W3138820503 cites W2150640434 @default.
• W3138820503 cites W2154714625 @default.
• W3138820503 cites W2163341755 @default.
• W3138820503 cites W2169707043 @default.
• W3138820503 cites W2169819811 @default.
• W3138820503 cites W2171159778 @default.
• W3138820503 cites W2172065733 @default.
• W3138820503 cites W2260165641 @default.
• W3138820503 cites W2749360192 @default.
• W3138820503 cites W2885598884 @default.
• W3138820503 cites W2933693058 @default.
• W3138820503 cites W2954866821 @default.
• W3138820503 cites W2967097619 @default.
• W3138820503 cites W3004795184 @default.
• W3138820503 cites W3025932081 @default.
• W3138820503 cites W3026191913 @default.
• W3138820503 cites W3094609706 @default.
• W3138820503 cites W4248872320 @default.
• W3138820503 doi "https://doi.org/10.1021/acs.biochem.1c00009" @default.
• W3138820503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33724805" @default.
• W3138820503 hasPublicationYear "2021" @default.
• W3138820503 type Work @default.
• W3138820503 sameAs 3138820503 @default.
• W3138820503 citedByCount "17" @default.
• W3138820503 countsByYear W31388205032021 @default.
• W3138820503 countsByYear W31388205032022 @default.
• W3138820503 countsByYear W31388205032023 @default.
• W3138820503 crossrefType "journal-article" @default.
• W3138820503 hasAuthorship W3138820503A5009089345 @default.
• W3138820503 hasAuthorship W3138820503A5017286913 @default.
• W3138820503 hasAuthorship W3138820503A5037336807 @default.
• W3138820503 hasAuthorship W3138820503A5057114335 @default.
• W3138820503 hasAuthorship W3138820503A5058559016 @default.
• W3138820503 hasAuthorship W3138820503A5063594309 @default.
• W3138820503 hasAuthorship W3138820503A5076449419 @default.
• W3138820503 hasAuthorship W3138820503A5077781498 @default.
• W3138820503 hasAuthorship W3138820503A5077818736 @default.
• W3138820503 hasAuthorship W3138820503A5078435865 @default.
• W3138820503 hasBestOaLocation W31388205031 @default.
• W3138820503 hasConcept C106257327 @default.
• W3138820503 hasConcept C108625454 @default.
• W3138820503 hasConcept C11569505 @default.
• W3138820503 hasConcept C170493617 @default.
• W3138820503 hasConcept C185592680 @default.
• W3138820503 hasConcept C202751555 @default.
• W3138820503 hasConcept C206212055 @default.
• W3138820503 hasConcept C24530287 @default.
• W3138820503 hasConcept C2776200302 @default.
• W3138820503 hasConcept C2780758401 @default.
• W3138820503 hasConcept C28005876 @default.
• W3138820503 hasConcept C55493867 @default.
• W3138820503 hasConcept C79747257 @default.

• next