FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138840574> ?p ?o ?g. }

• W3138840574 abstract "Abstract Following bacterial infection, macrophages produce pro-inflammatory cytokines in response to bacterial cell components, including lipopolysaccharide (LPS) and lipopeptide, and simultaneously phagocytize and digest the invading bacteria. To study the effects of phagocytosis on pro-inflammatory responses, we determined if phagocytosis of polystyrene latex beads with ~ 1 µm diameter increases pro-inflammatory cytokine expression by human macrophage-like U937 and THP-1 cells stimulated with LPS. Treating macrophage-like cells with beads coated with IgG to facilitate Fcγ receptor-mediated phagocytosis increased LPS-induced expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6. Treatment with beads coated with poly- l -lysine to facilitate Fcγ receptor–independent phagocytosis also increased LPS-induced cytokine expression. Our results indicate that LPS-induced pro-inflammatory responses are enhanced by bead phagocytosis regardless of the uptake mechanism. Additionally, phagocytosis enhanced LPS-induced NF-κB activation, suggesting that Toll-like receptor (TLR) 4 signaling is enhanced by phagocytosis. Furthermore, bead phagocytosis enhanced pro-inflammatory responses in U937 cells stimulated with lipopeptide, a ligand for the TLR2/TLR6 heterodimeric receptor. In conclusion, microparticle phagocytosis by macrophage-like U937 and THP-1 cells enhances the innate immune response induced by bacterial components." @default.
• W3138840574 created "2021-03-29" @default.
• W3138840574 creator A5061220478 @default.
• W3138840574 creator A5066304268 @default.
• W3138840574 creator A5070979785 @default.
• W3138840574 date "2021-03-24" @default.
• W3138840574 modified "2023-09-29" @default.
• W3138840574 title "Phagocytosis of microparticles increases responsiveness of macrophage-like cell lines U937 and THP-1 to bacterial lipopolysaccharide and lipopeptide" @default.
• W3138840574 cites W1125778144 @default.
• W3138840574 cites W1483162601 @default.
• W3138840574 cites W1519633296 @default.
• W3138840574 cites W1541731964 @default.
• W3138840574 cites W1606797793 @default.
• W3138840574 cites W183967228 @default.
• W3138840574 cites W1926532709 @default.
• W3138840574 cites W1968713831 @default.
• W3138840574 cites W1972776583 @default.
• W3138840574 cites W1989501301 @default.
• W3138840574 cites W1995098912 @default.
• W3138840574 cites W1995181730 @default.
• W3138840574 cites W1996671942 @default.
• W3138840574 cites W2000659418 @default.
• W3138840574 cites W2002298962 @default.
• W3138840574 cites W2013887826 @default.
• W3138840574 cites W2016730049 @default.
• W3138840574 cites W2016862474 @default.
• W3138840574 cites W2024446497 @default.
• W3138840574 cites W2028651845 @default.
• W3138840574 cites W2036261151 @default.
• W3138840574 cites W2041229448 @default.
• W3138840574 cites W2048126811 @default.
• W3138840574 cites W2050520078 @default.
• W3138840574 cites W2061937637 @default.
• W3138840574 cites W2062025882 @default.
• W3138840574 cites W2067722485 @default.
• W3138840574 cites W2076437861 @default.
• W3138840574 cites W2081654862 @default.
• W3138840574 cites W2086949509 @default.
• W3138840574 cites W2089430148 @default.
• W3138840574 cites W2092250990 @default.
• W3138840574 cites W2098901296 @default.
• W3138840574 cites W2098950066 @default.
• W3138840574 cites W2099288361 @default.
• W3138840574 cites W2102651889 @default.
• W3138840574 cites W2104783446 @default.
• W3138840574 cites W2112048948 @default.
• W3138840574 cites W2122708413 @default.
• W3138840574 cites W2129319296 @default.
• W3138840574 cites W2130421043 @default.
• W3138840574 cites W2142162924 @default.
• W3138840574 cites W2144203350 @default.
• W3138840574 cites W2144887013 @default.
• W3138840574 cites W2145078103 @default.
• W3138840574 cites W2145803213 @default.
• W3138840574 cites W2156788946 @default.
• W3138840574 cites W2162076795 @default.
• W3138840574 cites W2165947392 @default.
• W3138840574 cites W2166542918 @default.
• W3138840574 cites W2168320884 @default.
• W3138840574 cites W2323159543 @default.
• W3138840574 cites W2347188564 @default.
• W3138840574 cites W2579566490 @default.
• W3138840574 cites W2612459567 @default.
• W3138840574 cites W2625489207 @default.
• W3138840574 cites W2746941219 @default.
• W3138840574 cites W281542935 @default.
• W3138840574 cites W2896721670 @default.
• W3138840574 cites W2905076856 @default.
• W3138840574 cites W4243449974 @default.
• W3138840574 doi "https://doi.org/10.1038/s41598-021-86202-5" @default.
• W3138840574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7990916" @default.
• W3138840574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33762618" @default.
• W3138840574 hasPublicationYear "2021" @default.
• W3138840574 type Work @default.
• W3138840574 sameAs 3138840574 @default.
• W3138840574 citedByCount "7" @default.
• W3138840574 countsByYear W31388405742022 @default.
• W3138840574 countsByYear W31388405742023 @default.
• W3138840574 crossrefType "journal-article" @default.
• W3138840574 hasAuthorship W3138840574A5061220478 @default.
• W3138840574 hasAuthorship W3138840574A5066304268 @default.
• W3138840574 hasAuthorship W3138840574A5070979785 @default.
• W3138840574 hasBestOaLocation W31388405741 @default.
• W3138840574 hasConcept C108634530 @default.
• W3138840574 hasConcept C136449434 @default.
• W3138840574 hasConcept C160448771 @default.
• W3138840574 hasConcept C164027704 @default.
• W3138840574 hasConcept C170493617 @default.
• W3138840574 hasConcept C17991360 @default.
• W3138840574 hasConcept C185592680 @default.
• W3138840574 hasConcept C202751555 @default.
• W3138840574 hasConcept C203014093 @default.
• W3138840574 hasConcept C204258353 @default.
• W3138840574 hasConcept C2776914184 @default.
• W3138840574 hasConcept C2778690821 @default.
• W3138840574 hasConcept C2778754761 @default.
• W3138840574 hasConcept C2779244956 @default.
• W3138840574 hasConcept C2781236682 @default.
• W3138840574 hasConcept C2993002077 @default.
• W3138840574 hasConcept C54355233 @default.

• next