FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138840868> ?p ?o ?g. }

• W3138840868 endingPage "1818" @default.
• W3138840868 startingPage "1806" @default.
• W3138840868 abstract "Aims Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent disease. Physical exercise has been shown to alter disease progression in HFpEF. We examined cardiomyocyte Ca2+ homeostasis and left ventricular function in a metabolic HFpEF model in sedentary and trained rats following 8 weeks of moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT). Methods and results Left ventricular in vivo function (echocardiography) and cardiomyocyte Ca2+ transients (CaTs) (Fluo-4, confocal) were compared in ZSF-1 obese (metabolic syndrome, HFpEF) and ZSF-1 lean (control) 21- and 28-week-old rats. At 21 weeks, cardiomyocytes from HFpEF rats showed prolonged Ca2+ reuptake in cytosolic and nuclear CaTs and impaired Ca2+ release kinetics in nuclear CaTs. At 28 weeks, HFpEF cardiomyocytes had depressed CaT amplitudes, decreased sarcoplasmic reticulum (SR) Ca2+ content, increased SR Ca2+ leak, and elevated diastolic [Ca2+] following increased pacing rate (5 Hz). In trained HFpEF rats (HIIT or MICT), cardiomyocyte SR Ca2+ leak was significantly reduced. While HIIT had no effects on the CaTs (1–5 Hz), MICT accelerated early Ca2+ release, reduced the amplitude, and prolonged the CaT without increasing diastolic [Ca2+] or cytosolic Ca2+ load at basal or increased pacing rate (1–5 Hz). MICT lowered pro-arrhythmogenic Ca2+ sparks and attenuated Ca2+-wave propagation in cardiomyocytes. MICT was associated with increased stroke volume in HFpEF. Conclusions In this metabolic rat model of HFpEF at an advanced stage, Ca2+ release was impaired under baseline conditions. HIIT and MICT differentially affected Ca2+ homeostasis with positive effects of MICT on stroke volume, end-diastolic volume, and cellular arrhythmogenicity." @default.
• W3138840868 created "2021-03-29" @default.
• W3138840868 creator A5008130191 @default.
• W3138840868 creator A5009905903 @default.
• W3138840868 creator A5010783459 @default.
• W3138840868 creator A5017935429 @default.
• W3138840868 creator A5038761581 @default.
• W3138840868 creator A5038917567 @default.
• W3138840868 creator A5058705354 @default.
• W3138840868 creator A5064496908 @default.
• W3138840868 creator A5079589481 @default.
• W3138840868 creator A5080590382 @default.
• W3138840868 creator A5082153440 @default.
• W3138840868 creator A5088565799 @default.
• W3138840868 date "2021-03-25" @default.
• W3138840868 modified "2023-10-02" @default.
• W3138840868 title "Effects of different exercise modalities on cardiac dysfunction in heart failure with preserved ejection fraction" @default.
• W3138840868 cites W1249459315 @default.
• W3138840868 cites W1516799253 @default.
• W3138840868 cites W1582383085 @default.
• W3138840868 cites W1989500574 @default.
• W3138840868 cites W1995339146 @default.
• W3138840868 cites W2006610059 @default.
• W3138840868 cites W2021693681 @default.
• W3138840868 cites W2045019896 @default.
• W3138840868 cites W2050956829 @default.
• W3138840868 cites W2054909389 @default.
• W3138840868 cites W2075089321 @default.
• W3138840868 cites W2079424164 @default.
• W3138840868 cites W2099988884 @default.
• W3138840868 cites W2114986572 @default.
• W3138840868 cites W2148003915 @default.
• W3138840868 cites W2152263043 @default.
• W3138840868 cites W2153150734 @default.
• W3138840868 cites W2160479864 @default.
• W3138840868 cites W2162605088 @default.
• W3138840868 cites W2171221968 @default.
• W3138840868 cites W2346744204 @default.
• W3138840868 cites W2610625640 @default.
• W3138840868 cites W2743895735 @default.
• W3138840868 cites W2766228817 @default.
• W3138840868 cites W2778329517 @default.
• W3138840868 cites W2778333818 @default.
• W3138840868 cites W2781894023 @default.
• W3138840868 cites W2806524607 @default.
• W3138840868 cites W2887834916 @default.
• W3138840868 cites W2889341865 @default.
• W3138840868 cites W2889735779 @default.
• W3138840868 cites W2902201411 @default.
• W3138840868 cites W2905130449 @default.
• W3138840868 cites W2913497479 @default.
• W3138840868 cites W2917206166 @default.
• W3138840868 cites W2938295233 @default.
• W3138840868 cites W2972498190 @default.
• W3138840868 cites W2991623165 @default.
• W3138840868 doi "https://doi.org/10.1002/ehf2.13308" @default.
• W3138840868 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8120378" @default.
• W3138840868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33768692" @default.
• W3138840868 hasPublicationYear "2021" @default.
• W3138840868 type Work @default.
• W3138840868 sameAs 3138840868 @default.
• W3138840868 citedByCount "4" @default.
• W3138840868 countsByYear W31388408682021 @default.
• W3138840868 countsByYear W31388408682022 @default.
• W3138840868 countsByYear W31388408682023 @default.
• W3138840868 crossrefType "journal-article" @default.
• W3138840868 hasAuthorship W3138840868A5008130191 @default.
• W3138840868 hasAuthorship W3138840868A5009905903 @default.
• W3138840868 hasAuthorship W3138840868A5010783459 @default.
• W3138840868 hasAuthorship W3138840868A5017935429 @default.
• W3138840868 hasAuthorship W3138840868A5038761581 @default.
• W3138840868 hasAuthorship W3138840868A5038917567 @default.
• W3138840868 hasAuthorship W3138840868A5058705354 @default.
• W3138840868 hasAuthorship W3138840868A5064496908 @default.
• W3138840868 hasAuthorship W3138840868A5079589481 @default.
• W3138840868 hasAuthorship W3138840868A5080590382 @default.
• W3138840868 hasAuthorship W3138840868A5082153440 @default.
• W3138840868 hasAuthorship W3138840868A5088565799 @default.
• W3138840868 hasBestOaLocation W31388408682 @default.
• W3138840868 hasConcept C126322002 @default.
• W3138840868 hasConcept C134018914 @default.
• W3138840868 hasConcept C164705383 @default.
• W3138840868 hasConcept C2777099384 @default.
• W3138840868 hasConcept C2778198053 @default.
• W3138840868 hasConcept C57900726 @default.
• W3138840868 hasConcept C63645605 @default.
• W3138840868 hasConcept C71924100 @default.
• W3138840868 hasConcept C78085059 @default.
• W3138840868 hasConcept C80461066 @default.
• W3138840868 hasConcept C84393581 @default.
• W3138840868 hasConceptScore W3138840868C126322002 @default.
• W3138840868 hasConceptScore W3138840868C134018914 @default.
• W3138840868 hasConceptScore W3138840868C164705383 @default.
• W3138840868 hasConceptScore W3138840868C2777099384 @default.
• W3138840868 hasConceptScore W3138840868C2778198053 @default.
• W3138840868 hasConceptScore W3138840868C57900726 @default.
• W3138840868 hasConceptScore W3138840868C63645605 @default.
• W3138840868 hasConceptScore W3138840868C71924100 @default.

• next