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- W3138862925 abstract "T4N0M0 (size > 7cm) non-small cell lung cancer (NSCLC) represent relatively favorable prognosis in stage IIIA category, probably due to the limited metastatic potential. The intratumor genomic profile of these oversize tumors have not been well studied. T4N0M0 surgical NSCLC patients were enrolled. Whole-exome sequencing on three regions of each surgical tumor was performed. Single nucleotide variation (SNV), small insertion and deletions (Indels), and copy number variation were called and used for the analysis of intratumoral heterogeneity (ITH). Driver genes were identified by a gene list from the research of Matthew H. Bailey 2018. Tumor mutation burden (TMB) was calculated using all somatic nonsynonymous mutations (variant allele frequency > 0.03). Phylogenetic trees were constructed by regionally shared and private alterations. Five NSCLC were enrolled, including three adenocarcinoma and two squamous cell carcinoma. 15 tumor regions were sequenced successfully, with a median coverage of 452×. Interestingly, two distant ITH/TMB phenotypes were found, ITHlow/TMBhi (P1,P4,P5) andITHhi/TMBlow (P2,P3). The average heterogeneous somatic mutations in these two categories were 36% vs 98%, while the TMB was 154 vs 19. The ITHlow/TMBhi type had higher proportion of trunk SNV and Indels (62.2%, 53.2, and 65.5%, respectively), while ITHhi/TMBlow had lower of trunk (0% and 3.2%). In total, 11 driver mutations were identified and 72.73% of the driver mutations located on the trunks of tumor phylogenetic trees, including KEAP1, TP53, FAT1, CDKN2A, SMARCA4, and FAT1. Our data implied two distant ITH/TMB phenotypes in the T4N0M0 NSCLC (>7cm). It may contribute to our need for further understanding of tumor indolent growth pattern." @default.
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- W3138862925 date "2021-03-01" @default.
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- W3138862925 title "P59.03 Intratumoral Heterogeneity and Clonal Evolution in Large Non-Small Cell Lung Cancer (>7cm) Delineated by Multiregion Sequencing" @default.
- W3138862925 doi "https://doi.org/10.1016/j.jtho.2021.01.954" @default.
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