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- W3138889251 abstract "As a model radio-photodynamic therapy (RPDT) agent, we developed a multicomponent nanomaterial by anchoring conjugated chromophores on the surface of scintillating chrysotile nanotubes. Its ultimate composition makes the system a scintillation-activated photosensitizer for the singlet oxygen production. This nanomaterial shows a remarkable ability to enhance the production of singlet oxygen in an aqueous environment, under X-ray irradiation, boosting its production by almost 1 order of magnitude. Its efficiency as a coadjutant for radiotherapy has been tested in vitro, showing a striking efficacy in enhancing both the prompt cytotoxicity of the ionizing radiation and the long-term cytotoxicity given by radiation-activated apoptosis. Notably, the beneficial activity of the RPDT agent is prominent at low levels of delivered doses comparable to the one employed in clinical treatments. This opens the possibility of effectively reducing the therapy exposure and consequently undesired collateral effects due to prolonged exposure of patients to high-energy radiation." @default.
- W3138889251 created "2021-03-29" @default.
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- W3138889251 date "2021-03-15" @default.
- W3138889251 modified "2023-09-23" @default.
- W3138889251 title "Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer" @default.
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- W3138889251 doi "https://doi.org/10.1021/acsami.1c02504" @default.
- W3138889251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8153399" @default.
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