Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138889346> ?p ?o ?g. }
- W3138889346 endingPage "e1009438" @default.
- W3138889346 startingPage "e1009438" @default.
- W3138889346 abstract "Circular RNAs (circRNAs) represent a class of widespread and diverse covalently closed circular endogenous RNAs that exert crucial functions in regulating gene expression in mammals. However, the function and regulation mechanism of circRNAs in lower vertebrates are still unknown. Here, we discovered a novel circRNA derived from Deltex E3 ubiquitin ligase 1 ( Dtx1 ) gene, namely, circDtx1, which was related to the antiviral responses in teleost fish. Results indicated that circDtx1 played essential roles in host antiviral immunity and inhibition of SCRV replication. Our study also found a microRNA miR-15a-5p, which could inhibit antiviral immune response and promote viral replication by targeting TRIF. Moreover, we also found that the antiviral effect inhibited by miR-15a-5p could be reversed with the circDtx1. In mechanism, our data revealed that circDtx1 was a competing endogenous RNA (ceRNA) of TRIF by sponging miR-15a-5p, leading to activation of the NF-κB/IRF3 pathway, and then enhancing the innate antiviral responses. Our results indicated that circRNAs played a regulatory role in immune responses in teleost fish." @default.
- W3138889346 created "2021-03-29" @default.
- W3138889346 creator A5017826971 @default.
- W3138889346 creator A5018931275 @default.
- W3138889346 creator A5036072186 @default.
- W3138889346 creator A5061456448 @default.
- W3138889346 creator A5077170267 @default.
- W3138889346 date "2021-03-18" @default.
- W3138889346 modified "2023-10-09" @default.
- W3138889346 title "Circular RNA circDtx1 regulates IRF3-mediated antiviral immune responses through suppression of miR-15a-5p-dependent TRIF downregulation in teleost fish" @default.
- W3138889346 cites W1499978168 @default.
- W3138889346 cites W1521279639 @default.
- W3138889346 cites W1733534154 @default.
- W3138889346 cites W1974138334 @default.
- W3138889346 cites W1985286504 @default.
- W3138889346 cites W1985968246 @default.
- W3138889346 cites W1991647854 @default.
- W3138889346 cites W1994942139 @default.
- W3138889346 cites W2003385732 @default.
- W3138889346 cites W2016755802 @default.
- W3138889346 cites W2019234632 @default.
- W3138889346 cites W2031593782 @default.
- W3138889346 cites W2034305079 @default.
- W3138889346 cites W2034412957 @default.
- W3138889346 cites W2046387002 @default.
- W3138889346 cites W2055493067 @default.
- W3138889346 cites W2058835062 @default.
- W3138889346 cites W2064024180 @default.
- W3138889346 cites W2064165694 @default.
- W3138889346 cites W2065445260 @default.
- W3138889346 cites W2071162967 @default.
- W3138889346 cites W2076361525 @default.
- W3138889346 cites W2077889120 @default.
- W3138889346 cites W2091114810 @default.
- W3138889346 cites W2093773243 @default.
- W3138889346 cites W2096388504 @default.
- W3138889346 cites W2100305481 @default.
- W3138889346 cites W2102550380 @default.
- W3138889346 cites W2122045212 @default.
- W3138889346 cites W2129189537 @default.
- W3138889346 cites W2130421043 @default.
- W3138889346 cites W2139399606 @default.
- W3138889346 cites W2147806662 @default.
- W3138889346 cites W2152719653 @default.
- W3138889346 cites W2152842365 @default.
- W3138889346 cites W2152985701 @default.
- W3138889346 cites W2158582298 @default.
- W3138889346 cites W2159444732 @default.
- W3138889346 cites W2166411505 @default.
- W3138889346 cites W2169727478 @default.
- W3138889346 cites W2331419903 @default.
- W3138889346 cites W2473991067 @default.
- W3138889346 cites W2584901479 @default.
- W3138889346 cites W2590028890 @default.
- W3138889346 cites W2591124474 @default.
- W3138889346 cites W2604434684 @default.
- W3138889346 cites W2618478064 @default.
- W3138889346 cites W2669431949 @default.
- W3138889346 cites W2776340130 @default.
- W3138889346 cites W2799607502 @default.
- W3138889346 cites W2811388126 @default.
- W3138889346 cites W2943283123 @default.
- W3138889346 cites W2964331590 @default.
- W3138889346 cites W3038293452 @default.
- W3138889346 cites W3043132260 @default.
- W3138889346 cites W4231935988 @default.
- W3138889346 doi "https://doi.org/10.1371/journal.ppat.1009438" @default.
- W3138889346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8009406" @default.
- W3138889346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33735323" @default.
- W3138889346 hasPublicationYear "2021" @default.
- W3138889346 type Work @default.
- W3138889346 sameAs 3138889346 @default.
- W3138889346 citedByCount "35" @default.
- W3138889346 countsByYear W31388893462021 @default.
- W3138889346 countsByYear W31388893462022 @default.
- W3138889346 countsByYear W31388893462023 @default.
- W3138889346 crossrefType "journal-article" @default.
- W3138889346 hasAuthorship W3138889346A5017826971 @default.
- W3138889346 hasAuthorship W3138889346A5018931275 @default.
- W3138889346 hasAuthorship W3138889346A5036072186 @default.
- W3138889346 hasAuthorship W3138889346A5061456448 @default.
- W3138889346 hasAuthorship W3138889346A5077170267 @default.
- W3138889346 hasBestOaLocation W31388893461 @default.
- W3138889346 hasConcept C104317684 @default.
- W3138889346 hasConcept C127561419 @default.
- W3138889346 hasConcept C134459356 @default.
- W3138889346 hasConcept C136449434 @default.
- W3138889346 hasConcept C140704245 @default.
- W3138889346 hasConcept C145059251 @default.
- W3138889346 hasConcept C159047783 @default.
- W3138889346 hasConcept C203014093 @default.
- W3138889346 hasConcept C2522874641 @default.
- W3138889346 hasConcept C25602115 @default.
- W3138889346 hasConcept C2775893923 @default.
- W3138889346 hasConcept C2776709828 @default.
- W3138889346 hasConcept C2780209191 @default.
- W3138889346 hasConcept C43929388 @default.
- W3138889346 hasConcept C54355233 @default.