Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138905471> ?p ?o ?g. }
- W3138905471 endingPage "102272" @default.
- W3138905471 startingPage "102272" @default.
- W3138905471 abstract "Bovine endometrium infection with gram-negative bacteria commonly causes uterine diseases. Previous studies indicate that prostaglandin E2 (PGE2) is an inflammatory mediator in bacterial endometritis. However, the mechanism underlying lipopolysaccharide (LPS)-induced inflammatory response regulation in bovine endometrial explants remains elusive. In the present study, bovine explants were pre-treated with 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitors before LPS stimulation. PGE2 secretion, prostaglandin synthetase, pro-inflammatory factor, damage-associated molecular pattern (DAMP), and related signaling pathway factor levels were evaluated. Using 15-PGDH inhibitors pre-treatment, LPS-treated bovine endometrial explants exhibited augmentation of PGE2 and DAMP expression, and upregulation of various signaling pathway factors. Protein kinase A (PKA), extracellular-signal-regulated kinase, and c-Jun N-terminal kinase phosphorylation and degradation of nuclear transcription factor-κB (NF-κB) inhibitors were induced in the pre-treated endometrial explants. The mechanism underlying LPS-induced PGE2 accumulation acting as a pro-inflammatory mediator through toll-like receptor 4 signaling in bovine explants could involve the PKA, mitogen-activated protein kinase, and NF-κB pathways." @default.
- W3138905471 created "2021-03-29" @default.
- W3138905471 creator A5000128482 @default.
- W3138905471 creator A5012074083 @default.
- W3138905471 creator A5020199147 @default.
- W3138905471 creator A5038620841 @default.
- W3138905471 creator A5050501022 @default.
- W3138905471 creator A5052022779 @default.
- W3138905471 creator A5062399129 @default.
- W3138905471 creator A5063620011 @default.
- W3138905471 creator A5072883829 @default.
- W3138905471 date "2021-05-01" @default.
- W3138905471 modified "2023-09-27" @default.
- W3138905471 title "Lipopolysaccharide stimulates bovine endometrium explants through toll‑like receptor 4 signaling and PGE2 synthesis" @default.
- W3138905471 cites W1551721144 @default.
- W3138905471 cites W1963573509 @default.
- W3138905471 cites W1966460970 @default.
- W3138905471 cites W1973557693 @default.
- W3138905471 cites W1980548660 @default.
- W3138905471 cites W1981993831 @default.
- W3138905471 cites W1983735472 @default.
- W3138905471 cites W1983769980 @default.
- W3138905471 cites W1987021426 @default.
- W3138905471 cites W1994942139 @default.
- W3138905471 cites W1995744610 @default.
- W3138905471 cites W1999643718 @default.
- W3138905471 cites W2004266769 @default.
- W3138905471 cites W2008932880 @default.
- W3138905471 cites W2013469022 @default.
- W3138905471 cites W2021737033 @default.
- W3138905471 cites W2039812366 @default.
- W3138905471 cites W2040458759 @default.
- W3138905471 cites W2042433863 @default.
- W3138905471 cites W2042812583 @default.
- W3138905471 cites W2043823247 @default.
- W3138905471 cites W2043958179 @default.
- W3138905471 cites W2050321932 @default.
- W3138905471 cites W2054426074 @default.
- W3138905471 cites W2081156978 @default.
- W3138905471 cites W2090285073 @default.
- W3138905471 cites W2094755730 @default.
- W3138905471 cites W2107277218 @default.
- W3138905471 cites W2108265672 @default.
- W3138905471 cites W2113646062 @default.
- W3138905471 cites W2123816220 @default.
- W3138905471 cites W2125167727 @default.
- W3138905471 cites W2126552441 @default.
- W3138905471 cites W2127934565 @default.
- W3138905471 cites W2129746956 @default.
- W3138905471 cites W2138819828 @default.
- W3138905471 cites W2142638240 @default.
- W3138905471 cites W2147365776 @default.
- W3138905471 cites W2147412811 @default.
- W3138905471 cites W2152967534 @default.
- W3138905471 cites W2157341902 @default.
- W3138905471 cites W2168362891 @default.
- W3138905471 cites W2339656438 @default.
- W3138905471 cites W2403301801 @default.
- W3138905471 cites W2518938504 @default.
- W3138905471 cites W2696939191 @default.
- W3138905471 cites W2790127349 @default.
- W3138905471 cites W2884090576 @default.
- W3138905471 cites W2933795008 @default.
- W3138905471 cites W2963321302 @default.
- W3138905471 cites W923747514 @default.
- W3138905471 doi "https://doi.org/10.1016/j.plefa.2021.102272" @default.
- W3138905471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33895679" @default.
- W3138905471 hasPublicationYear "2021" @default.
- W3138905471 type Work @default.
- W3138905471 sameAs 3138905471 @default.
- W3138905471 citedByCount "2" @default.
- W3138905471 countsByYear W31389054712021 @default.
- W3138905471 countsByYear W31389054712022 @default.
- W3138905471 crossrefType "journal-article" @default.
- W3138905471 hasAuthorship W3138905471A5000128482 @default.
- W3138905471 hasAuthorship W3138905471A5012074083 @default.
- W3138905471 hasAuthorship W3138905471A5020199147 @default.
- W3138905471 hasAuthorship W3138905471A5038620841 @default.
- W3138905471 hasAuthorship W3138905471A5050501022 @default.
- W3138905471 hasAuthorship W3138905471A5052022779 @default.
- W3138905471 hasAuthorship W3138905471A5062399129 @default.
- W3138905471 hasAuthorship W3138905471A5063620011 @default.
- W3138905471 hasAuthorship W3138905471A5072883829 @default.
- W3138905471 hasConcept C126322002 @default.
- W3138905471 hasConcept C134018914 @default.
- W3138905471 hasConcept C136449434 @default.
- W3138905471 hasConcept C170493617 @default.
- W3138905471 hasConcept C178592051 @default.
- W3138905471 hasConcept C184235292 @default.
- W3138905471 hasConcept C2775846227 @default.
- W3138905471 hasConcept C2776709828 @default.
- W3138905471 hasConcept C2778754761 @default.
- W3138905471 hasConcept C2778938600 @default.
- W3138905471 hasConcept C2779234561 @default.
- W3138905471 hasConcept C2779742232 @default.
- W3138905471 hasConcept C2780664492 @default.
- W3138905471 hasConcept C54355233 @default.
- W3138905471 hasConcept C55493867 @default.