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• W3138914839 abstract "Cells respond to stress by blocking translation, rewiring metabolism and forming transient messenger ribonucleoprotein assemblies called stress granules (SGs). After stress release, re-establishing homeostasis and disassembling SGs requires ATP-consuming processes. However, the molecular mechanisms whereby cells restore ATP production and disassemble SGs after stress remain poorly understood. Here we show that upon stress, the ATP-producing enzyme Cdc19 forms inactive amyloids, and that their rapid re-solubilization is essential to restore ATP production and disassemble SGs in glucose-containing media. Cdc19 re-solubilization is initiated by the glycolytic metabolite fructose-1,6-bisphosphate, which directly binds Cdc19 amyloids, allowing Hsp104 and Ssa2 chaperone recruitment and aggregate re-solubilization. Fructose-1,6-bisphosphate then promotes Cdc19 tetramerization, which boosts its activity to further enhance ATP production and SG disassembly. Together, these results describe a molecular mechanism that is critical for stress recovery and directly couples cellular metabolism with SG dynamics via the regulation of reversible Cdc19 amyloids. Cereghetti et al. report that the glycolytic metabolite fructose-1,6-bisphosphate initiates the disassembly of amyloids formed by the yeast pyruvate kinase Cdc19 to resume ATP production during stress recovery." @default.
• W3138914839 created "2021-03-29" @default.
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• W3138914839 date "2021-10-01" @default.
• W3138914839 modified "2023-10-15" @default.
• W3138914839 title "Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly" @default.
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• W3138914839 doi "https://doi.org/10.1038/s41556-021-00760-4" @default.
• W3138914839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7611853" @default.
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