FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138924300> ?p ?o ?g. }

• W3138924300 abstract "As the core component of the adherens junction in cell-cell adhesion, the cadherin-catenin complex transduces mechanical tension between neighboring cells. Structural studies have shown that the cadherin-catenin complex exists as an ensemble of flexible conformations, with the actin-binding domain (ABD) of α-catenin adopting a variety of configurations. Here, we have determined the nanoscale protein domain dynamics of the cadherin-catenin complex using neutron spin echo spectroscopy (NSE), selective deuteration, and theoretical physics analyses. NSE reveals that, in the cadherin-catenin complex, the motion of the entire ABD becomes activated on nanosecond to submicrosecond timescales. By contrast, in the α-catenin homodimer, only the smaller disordered C-terminal tail of ABD is moving. Molecular dynamics (MD) simulations also show increased mobility of ABD in the cadherin-catenin complex, compared to the α-catenin homodimer. Biased MD simulations further reveal that the applied external forces promote the transition of ABD in the cadherin-catenin complex from an ensemble of diverse conformational states to specific states that resemble the actin-bound structure. The activated motion and an ensemble of flexible configurations of the mechanosensory ABD suggest the formation of an entropic trap in the cadherin-catenin complex, serving as negative allosteric regulation that impedes the complex from binding to actin under zero force. Mechanical tension facilitates the reduction in dynamics and narrows the conformational ensemble of ABD to specific configurations that are well suited to bind F-actin. Our results provide a protein dynamics and entropic explanation for the observed force-sensitive binding behavior of a mechanosensitive protein complex." @default.
• W3138924300 created "2021-03-29" @default.
• W3138924300 creator A5018868348 @default.
• W3138924300 creator A5023403293 @default.
• W3138924300 creator A5032756035 @default.
• W3138924300 creator A5036699619 @default.
• W3138924300 creator A5049309293 @default.
• W3138924300 creator A5078952328 @default.
• W3138924300 date "2021-03-22" @default.
• W3138924300 modified "2023-10-03" @default.
• W3138924300 title "Activated nanoscale actin-binding domain motion in the catenin–cadherin complex revealed by neutron spin echo spectroscopy" @default.
• W3138924300 cites W1493497001 @default.
• W3138924300 cites W1586431212 @default.
• W3138924300 cites W1866104439 @default.
• W3138924300 cites W1875724897 @default.
• W3138924300 cites W1970570245 @default.
• W3138924300 cites W1972076214 @default.
• W3138924300 cites W1981184799 @default.
• W3138924300 cites W1985191095 @default.
• W3138924300 cites W1985837832 @default.
• W3138924300 cites W1998551458 @default.
• W3138924300 cites W1999229632 @default.
• W3138924300 cites W2009688266 @default.
• W3138924300 cites W2013394636 @default.
• W3138924300 cites W2018638940 @default.
• W3138924300 cites W2019621646 @default.
• W3138924300 cites W2025735516 @default.
• W3138924300 cites W2028813239 @default.
• W3138924300 cites W2031841424 @default.
• W3138924300 cites W2036496674 @default.
• W3138924300 cites W2044730187 @default.
• W3138924300 cites W2050739806 @default.
• W3138924300 cites W2052492533 @default.
• W3138924300 cites W2062769155 @default.
• W3138924300 cites W2087871271 @default.
• W3138924300 cites W2088376141 @default.
• W3138924300 cites W2089368828 @default.
• W3138924300 cites W2097674158 @default.
• W3138924300 cites W2098708985 @default.
• W3138924300 cites W2101476328 @default.
• W3138924300 cites W2107149310 @default.
• W3138924300 cites W2109542099 @default.
• W3138924300 cites W2111072594 @default.
• W3138924300 cites W2114245165 @default.
• W3138924300 cites W2115969602 @default.
• W3138924300 cites W2119658007 @default.
• W3138924300 cites W2128493116 @default.
• W3138924300 cites W2132375258 @default.
• W3138924300 cites W2139676627 @default.
• W3138924300 cites W2142381589 @default.
• W3138924300 cites W2143646667 @default.
• W3138924300 cites W2155590711 @default.
• W3138924300 cites W2155708268 @default.
• W3138924300 cites W2159304854 @default.
• W3138924300 cites W2160648230 @default.
• W3138924300 cites W2161244514 @default.
• W3138924300 cites W2166529760 @default.
• W3138924300 cites W2292301738 @default.
• W3138924300 cites W2317283564 @default.
• W3138924300 cites W2433805774 @default.
• W3138924300 cites W2461967856 @default.
• W3138924300 cites W2531665193 @default.
• W3138924300 cites W2577512618 @default.
• W3138924300 cites W2588933908 @default.
• W3138924300 cites W2593109199 @default.
• W3138924300 cites W2594337808 @default.
• W3138924300 cites W2606724680 @default.
• W3138924300 cites W2748279491 @default.
• W3138924300 cites W2751930531 @default.
• W3138924300 cites W2765387868 @default.
• W3138924300 cites W2793224366 @default.
• W3138924300 cites W2803328077 @default.
• W3138924300 cites W2837964996 @default.
• W3138924300 cites W2896243061 @default.
• W3138924300 cites W2903559354 @default.
• W3138924300 cites W2908968323 @default.
• W3138924300 cites W2914798429 @default.
• W3138924300 cites W2920879064 @default.
• W3138924300 cites W2952430940 @default.
• W3138924300 cites W2954832902 @default.
• W3138924300 cites W2963886278 @default.
• W3138924300 cites W2979505241 @default.
• W3138924300 cites W2981932817 @default.
• W3138924300 cites W2998273600 @default.
• W3138924300 cites W3004209032 @default.
• W3138924300 cites W3014023546 @default.
• W3138924300 cites W3085850501 @default.
• W3138924300 cites W3088772533 @default.
• W3138924300 cites W35601271 @default.
• W3138924300 cites W635642784 @default.
• W3138924300 doi "https://doi.org/10.1073/pnas.2025012118" @default.
• W3138924300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8020631" @default.
• W3138924300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33753508" @default.
• W3138924300 hasPublicationYear "2021" @default.
• W3138924300 type Work @default.
• W3138924300 sameAs 3138924300 @default.
• W3138924300 citedByCount "6" @default.
• W3138924300 countsByYear W31389243002022 @default.
• W3138924300 countsByYear W31389243002023 @default.
• W3138924300 crossrefType "journal-article" @default.

• next