Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138927870> ?p ?o ?g. }
- W3138927870 abstract "Abstract The promise of human induced pluripotent stem cells (iPSCs) lies in their ability to serve as a starting material for autologous, or patient‐specific, stem cell–based therapies. Since the first publications describing the generation of iPSCs from human tissue in 2007, a Phase I/IIa clinical trial testing an autologous iPSC‐derived cell therapy has been initiated in the U.S., and several other autologous iPSC‐based therapies have advanced through various stages of development. Three single‐patient in‐human transplants of autologous iPSC‐derived cells have taken place worldwide. None of the patients suffered serious adverse events, despite not undergoing immunosuppression. These promising outcomes support the proposed advantage of an autologous approach: a cell therapy product that can engraft without the risk of immune rejection, eliminating the need for immunosuppression and the associated side effects. Despite this advantage, there are currently more allogeneic than autologous iPSC‐based cell therapy products in development due to the cost and complexity of scaling out manufacturing for each patient. In this review, we highlight recent progress toward clinical translation of autologous iPSC‐based cell therapies. We also highlight technological advancements that would reduce the cost and complexity of autologous iPSC‐based cell therapy production, enabling autologous iPSC‐based therapies to become a more commonplace treatment modality for patients. © 2021 The Authors." @default.
- W3138927870 created "2021-03-29" @default.
- W3138927870 creator A5036184675 @default.
- W3138927870 creator A5041405861 @default.
- W3138927870 creator A5061001837 @default.
- W3138927870 creator A5084762556 @default.
- W3138927870 date "2021-03-01" @default.
- W3138927870 modified "2023-10-06" @default.
- W3138927870 title "Autologous Induced Pluripotent Stem Cell–Based Cell Therapies: Promise, Progress, and Challenges" @default.
- W3138927870 cites W1519240899 @default.
- W3138927870 cites W1866157615 @default.
- W3138927870 cites W1872500596 @default.
- W3138927870 cites W1882758100 @default.
- W3138927870 cites W1894559552 @default.
- W3138927870 cites W1904477962 @default.
- W3138927870 cites W1917316786 @default.
- W3138927870 cites W1928967941 @default.
- W3138927870 cites W1964294710 @default.
- W3138927870 cites W1967025085 @default.
- W3138927870 cites W1967188390 @default.
- W3138927870 cites W1970561503 @default.
- W3138927870 cites W1973383520 @default.
- W3138927870 cites W1975207448 @default.
- W3138927870 cites W1975617773 @default.
- W3138927870 cites W1985913191 @default.
- W3138927870 cites W1986751115 @default.
- W3138927870 cites W1991107962 @default.
- W3138927870 cites W1995140705 @default.
- W3138927870 cites W1995478328 @default.
- W3138927870 cites W1999919809 @default.
- W3138927870 cites W2002766976 @default.
- W3138927870 cites W2012180911 @default.
- W3138927870 cites W2015500392 @default.
- W3138927870 cites W2015979204 @default.
- W3138927870 cites W2018848440 @default.
- W3138927870 cites W2019154801 @default.
- W3138927870 cites W2027156617 @default.
- W3138927870 cites W2029141700 @default.
- W3138927870 cites W2034460442 @default.
- W3138927870 cites W2035121417 @default.
- W3138927870 cites W2041983142 @default.
- W3138927870 cites W2051272245 @default.
- W3138927870 cites W2053911973 @default.
- W3138927870 cites W2058607314 @default.
- W3138927870 cites W2065564530 @default.
- W3138927870 cites W2070628315 @default.
- W3138927870 cites W2074283287 @default.
- W3138927870 cites W2076020457 @default.
- W3138927870 cites W2077806591 @default.
- W3138927870 cites W2083063722 @default.
- W3138927870 cites W2085600205 @default.
- W3138927870 cites W2088152986 @default.
- W3138927870 cites W2090210604 @default.
- W3138927870 cites W2098597036 @default.
- W3138927870 cites W2100465572 @default.
- W3138927870 cites W2108851964 @default.
- W3138927870 cites W2118972585 @default.
- W3138927870 cites W2124789204 @default.
- W3138927870 cites W2125111380 @default.
- W3138927870 cites W2130606072 @default.
- W3138927870 cites W2130749065 @default.
- W3138927870 cites W2130814631 @default.
- W3138927870 cites W2132551489 @default.
- W3138927870 cites W2134208433 @default.
- W3138927870 cites W2136440581 @default.
- W3138927870 cites W2138977668 @default.
- W3138927870 cites W2142046859 @default.
- W3138927870 cites W2146078700 @default.
- W3138927870 cites W2152392358 @default.
- W3138927870 cites W2152793450 @default.
- W3138927870 cites W2153411657 @default.
- W3138927870 cites W2154421213 @default.
- W3138927870 cites W2158391690 @default.
- W3138927870 cites W2158738402 @default.
- W3138927870 cites W2163441105 @default.
- W3138927870 cites W2167266797 @default.
- W3138927870 cites W2170098894 @default.
- W3138927870 cites W2170968177 @default.
- W3138927870 cites W2173737475 @default.
- W3138927870 cites W2268670797 @default.
- W3138927870 cites W2276835104 @default.
- W3138927870 cites W2278911990 @default.
- W3138927870 cites W2292805097 @default.
- W3138927870 cites W2344375165 @default.
- W3138927870 cites W2347094772 @default.
- W3138927870 cites W2401496253 @default.
- W3138927870 cites W2409273107 @default.
- W3138927870 cites W2477080920 @default.
- W3138927870 cites W2484437811 @default.
- W3138927870 cites W2542230947 @default.
- W3138927870 cites W2555665215 @default.
- W3138927870 cites W2559934670 @default.
- W3138927870 cites W2570036960 @default.
- W3138927870 cites W2570751506 @default.
- W3138927870 cites W2592644893 @default.
- W3138927870 cites W2597513824 @default.
- W3138927870 cites W2601350462 @default.
- W3138927870 cites W2613062475 @default.
- W3138927870 cites W2616215756 @default.
- W3138927870 cites W2757032260 @default.