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- W3138938712 abstract "Polo-like kinase 4 (PLK4) is canonically known for its cytoplasmic function in centriole duplication. Here we show a noncanonical PLK4 function of regulating the transcription factor SRF's nuclear activity and associated myofibroblast-like cell-type transition. In this context, we have further found that PLK4's phosphorylation and transcription are respectively regulated by PDGF receptor and epigenetic factor BRD4. Furthermore, in vivo experiments suggest PLK4 inhibition as a potential approach to mitigating vascular fibrosis." @default.
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- W3138938712 date "2021-03-01" @default.
- W3138938712 modified "2023-10-18" @default.
- W3138938712 title "A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition" @default.
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- W3138938712 doi "https://doi.org/10.1016/j.jacbts.2020.12.015" @default.
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