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- W3138944505 abstract "O-GlcNAcylation is a protein posttranslational modification that results in the addition of O-GlcNAc to Ser/Thr residues. Since its discovery in the 1980s, it has been shown to play an important role in a broad range of cellular functions by modifying nuclear, cytosolic, and mitochondrial proteins. The addition of O-GlcNAc is catalyzed by O-GlcNAc transferase (OGT), and its removal is catalyzed by O-GlcNAcase (OGA). Levels of protein O-GlcNAcylation change in response to nutrient availability and metabolic, oxidative, and proteotoxic stress. OGT and OGA levels, activity, and target engagement are also regulated. Together, this results in adaptive and, on occasions, detrimental responses that affect cellular function and survival, which impact a broad range of pathologies and aging. Over the past several decades, approaches and tools to aid the investigation of the regulation and consequences of protein O-GlcNAcylation have been developed and enhanced. This review is divided into two sections: 1) We will first focus on current standard and advanced technical approaches for assessing enzymatic activities of OGT and OGT, assessing the global and specific protein O-GlcNAcylation and 2) we will summarize in vivo findings of functional consequences of changing protein O-GlcNAcylation, using genetic and pharmacological approaches." @default.
- W3138944505 created "2021-03-29" @default.
- W3138944505 creator A5012370726 @default.
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- W3138944505 creator A5062506120 @default.
- W3138944505 creator A5070331230 @default.
- W3138944505 creator A5075235007 @default.
- W3138944505 date "2021-03-12" @default.
- W3138944505 modified "2023-10-16" @default.
- W3138944505 title "New Insights Into the Biology of Protein O-GlcNAcylation: Approaches and Observations" @default.
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