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• W3138948833 abstract "Fibrosis is a pathological process in diabetic nephropathy that causes renal failure and dysfunction. Given the known anti-diabetic effects of trans -Anethole (TA), we aimed to investigate its renoprotective and anti-fibrotic effect alone and in combination with losartan in diabetic nephropathy. Male Wistar rats received a single intraperitoneal injection of 65 mg/kg streptozotocin (STZ) for diabetes induction. Diabetic rats were treated orally with saline, TA (80 mg/kg), losartan (Los; 10 mg/kg), or the combination of TA and losartan (TA-Los) daily for five weeks. Renal function was monitored during the study, and renal fibrosis, oxidative stress markers, apoptotic cells, and the expression and localization of AT1R, TGF-β1, and Col-IV were detected in the kidney. Results showed that TA alone and in combination with losartan was able to decrease blood glucose, urea, and creatinine levels and improve kidney function parameters. TA, Los, and TA-Los significantly reduced tubule vascular degeneration, glomerular and tubulointerstitial sclerosis, oxidative stress, and apoptotic cells. Immunohistochemistry analyses showed that TA, losartan, and TA-losartan combination downregulated the AT1R, Col IV, and TGF-β1 expression and distribution in diabetic rat kidneys. Results suggest that TA is able to suppress diabetic nephropathy in rats effectively, probably by decreasing blood glucose levels and downregulating AT1R and TGF-β1 expression. • trans -Anethole ameliorated diabetic-associated renal injury. • trans -anethole improved GFR and reduced urinary glucose and protein excretion. • Renal fibrosis, apoptosis and oxidative stress reduced by trans -anethole. • trans -Anethole reduced AT1R and TGF-β1 expression in diabetic rats’ kidney. • Combined therapy with losartan enhanced the protective effects of trans -anethole." @default.
• W3138948833 created "2021-03-29" @default.
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• W3138948833 date "2021-06-01" @default.
• W3138948833 modified "2023-09-24" @default.
• W3138948833 title "trans-Anethole attenuated renal injury and reduced expressions of angiotensin II receptor (AT1R) and TGF-β in streptozotocin-induced diabetic rats" @default.
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• W3138948833 doi "https://doi.org/10.1016/j.biochi.2021.03.011" @default.
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