FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138973580> ?p ?o ?g. }

• W3138973580 endingPage "40" @default.
• W3138973580 startingPage "33" @default.
• W3138973580 abstract "Introduction: Chronic ethanol consumption leads to significant functional and structural changes in the mitochondria of the heart and brain, increasing generation of reactive oxygen species. Therefore, the search for substances, which improve the functional state of the mitochondria and, meantime, reduce the oxidative stress, is relevant.&#x0D; Materials and methods: 10-months-old Wistar female rats were used in the experiments. Chronic alcohol intoxication (CAI) was modelled by replacing drinking water with a 10% ethanol solution containing sucrose (50 g/L) for 24 weeks. Four groups were formed: 1 – intact animals; 2 – animals after chronic alcohol consumption; 3 – rats after CAI which were administered RSPU-260 (25 mg/kg); 4 – rats after CAI which were administered the reference drug Mildronate (50 mg/kg). The intensity of lipid peroxidation (LPO) and the rate of oxygen consumption in various metabolic states were determined.&#x0D; Results and discussion: Administration of the compound RSPU-260 to the animals exposed to alcohol over a long period of time resulted in an increase in both the rate of oxygen consumption (state 3) and the respiratory control ratio (RCR) of the mitochondria of heart and brain cells. The use of a GABA derivative promoted a decrease in malonic dialdehyde in the mitochondria of the heart and brain. Total SOD activity in the mitochondria of heart cells was significantly increased in the groups of rats treated with RSPU-260. In terms of efficiency, the compound RSPU-260 was comparable to the reference drug Mildronate.&#x0D; Conclusions: The compound RSPU-260, and the reference drug Mildronate improve mitochondrial oxidative phosphorylation in heart and brain cells, the functioning of antioxidant enzymes in animals after CAI, and can be used to correct alcoholic damage to these organs." @default.
• W3138973580 created "2021-03-29" @default.
• W3138973580 creator A5000586596 @default.
• W3138973580 creator A5001055093 @default.
• W3138973580 creator A5007674543 @default.
• W3138973580 creator A5008829962 @default.
• W3138973580 creator A5023603348 @default.
• W3138973580 creator A5026457196 @default.
• W3138973580 creator A5030822736 @default.
• W3138973580 creator A5047995247 @default.
• W3138973580 creator A5053935323 @default.
• W3138973580 creator A5085928166 @default.
• W3138973580 date "2021-03-23" @default.
• W3138973580 modified "2023-10-10" @default.
• W3138973580 title "Changes in the respiratory function of the heart and brain mitochondria of animals after chronic alcohol intoxication affected by a new GABA derivative" @default.
• W3138973580 cites W1573852374 @default.
• W3138973580 cites W1968590859 @default.
• W3138973580 cites W1999753655 @default.
• W3138973580 cites W2006179560 @default.
• W3138973580 cites W2007762852 @default.
• W3138973580 cites W2034159928 @default.
• W3138973580 cites W2041724276 @default.
• W3138973580 cites W2069734631 @default.
• W3138973580 cites W2095466935 @default.
• W3138973580 cites W2143505819 @default.
• W3138973580 cites W2150391242 @default.
• W3138973580 cites W2163694270 @default.
• W3138973580 cites W2229952668 @default.
• W3138973580 cites W2328530108 @default.
• W3138973580 cites W2341781352 @default.
• W3138973580 cites W2526344974 @default.
• W3138973580 cites W2622743229 @default.
• W3138973580 cites W2735452436 @default.
• W3138973580 cites W2773120347 @default.
• W3138973580 cites W2780288108 @default.
• W3138973580 cites W82585216 @default.
• W3138973580 cites W873214643 @default.
• W3138973580 doi "https://doi.org/10.3897/rrpharmacology.7.60469" @default.
• W3138973580 hasPublicationYear "2021" @default.
• W3138973580 type Work @default.
• W3138973580 sameAs 3138973580 @default.
• W3138973580 citedByCount "1" @default.
• W3138973580 countsByYear W31389735802022 @default.
• W3138973580 crossrefType "journal-article" @default.
• W3138973580 hasAuthorship W3138973580A5000586596 @default.
• W3138973580 hasAuthorship W3138973580A5001055093 @default.
• W3138973580 hasAuthorship W3138973580A5007674543 @default.
• W3138973580 hasAuthorship W3138973580A5008829962 @default.
• W3138973580 hasAuthorship W3138973580A5023603348 @default.
• W3138973580 hasAuthorship W3138973580A5026457196 @default.
• W3138973580 hasAuthorship W3138973580A5030822736 @default.
• W3138973580 hasAuthorship W3138973580A5047995247 @default.
• W3138973580 hasAuthorship W3138973580A5053935323 @default.
• W3138973580 hasAuthorship W3138973580A5085928166 @default.
• W3138973580 hasBestOaLocation W31389735801 @default.
• W3138973580 hasConcept C126322002 @default.
• W3138973580 hasConcept C134018914 @default.
• W3138973580 hasConcept C185592680 @default.
• W3138973580 hasConcept C2776151105 @default.
• W3138973580 hasConcept C2777953023 @default.
• W3138973580 hasConcept C2780035454 @default.
• W3138973580 hasConcept C2780161600 @default.
• W3138973580 hasConcept C2780829032 @default.
• W3138973580 hasConcept C2781066024 @default.
• W3138973580 hasConcept C28859421 @default.
• W3138973580 hasConcept C48349386 @default.
• W3138973580 hasConcept C534529494 @default.
• W3138973580 hasConcept C55493867 @default.
• W3138973580 hasConcept C71924100 @default.
• W3138973580 hasConcept C84393581 @default.
• W3138973580 hasConcept C98274493 @default.
• W3138973580 hasConceptScore W3138973580C126322002 @default.
• W3138973580 hasConceptScore W3138973580C134018914 @default.
• W3138973580 hasConceptScore W3138973580C185592680 @default.
• W3138973580 hasConceptScore W3138973580C2776151105 @default.
• W3138973580 hasConceptScore W3138973580C2777953023 @default.
• W3138973580 hasConceptScore W3138973580C2780035454 @default.
• W3138973580 hasConceptScore W3138973580C2780161600 @default.
• W3138973580 hasConceptScore W3138973580C2780829032 @default.
• W3138973580 hasConceptScore W3138973580C2781066024 @default.
• W3138973580 hasConceptScore W3138973580C28859421 @default.
• W3138973580 hasConceptScore W3138973580C48349386 @default.
• W3138973580 hasConceptScore W3138973580C534529494 @default.
• W3138973580 hasConceptScore W3138973580C55493867 @default.
• W3138973580 hasConceptScore W3138973580C71924100 @default.
• W3138973580 hasConceptScore W3138973580C84393581 @default.
• W3138973580 hasConceptScore W3138973580C98274493 @default.
• W3138973580 hasIssue "1" @default.
• W3138973580 hasLocation W31389735801 @default.
• W3138973580 hasLocation W31389735802 @default.
• W3138973580 hasLocation W31389735803 @default.
• W3138973580 hasOpenAccess W3138973580 @default.
• W3138973580 hasPrimaryLocation W31389735801 @default.
• W3138973580 hasRelatedWork W1470000624 @default.
• W3138973580 hasRelatedWork W1528674127 @default.
• W3138973580 hasRelatedWork W2328530460 @default.
• W3138973580 hasRelatedWork W2335044792 @default.
• W3138973580 hasRelatedWork W2400395252 @default.

• next