FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138973995> ?p ?o ?g. }

• W3138973995 abstract "Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is rare in Asians, and patients with CLL/SLL seldomly undergo kidney biopsy. The histopathological features and clinical relevance of tubulointerstitial injury in CLL/SLL have not been extensively characterized. Hence, we attempted to describe the clinical characteristics, renal pathology and clinical outcome of a well-characterized population of CLL/SLL patients with CLL cell infiltration in the renal interstitium from a large single center in China.Between January 1st, 2010 and September 31st, 2020, 31946renal biopsies were performed at Peking University First Hospital, and 10 CLL/SLL patients with CLL cell infiltration in the renal interstitium were included. Complete clinical data were collected from these 10 patients, and renal specimens were examined by routine light microscopy, immunofluorescence and electron microscopy.The extent of the infiltrating CLL cells in patients with CLL/SLL varied among different patients and ranged from 10 to 90% of kidney parenchyma. Six (60%) of 10 patients presented with an extent of infiltrating CLL cells ≥50%. Interestingly, we found that three patients (3/10, 30%) expressed monoclonal immunoglobulins in the infiltrating CLL cells, and special cytoplasmic crystalline structures were found in two of the three patients by electron microscopy for the first time. Severe renal insufficiency (Scr ≥200 μmol/L) was associated with ≥50% interstitial infiltration of CLL cells in the renal interstitium.The current study confirmed that CLL cells infiltrating the renal interstitium can directly secrete monoclonal immunoglobulins, indicating that the interstitial infiltrating CLL cells possibly cause renal injury directly by secreting monoclonal immunoglobulins in situ. This finding may prove a new clue to elucidate the pathogenetic mechanism of renal injury involved with CLL/SLL." @default.
• W3138973995 created "2021-03-29" @default.
• W3138973995 creator A5008236609 @default.
• W3138973995 creator A5063193909 @default.
• W3138973995 creator A5074670181 @default.
• W3138973995 creator A5090366405 @default.
• W3138973995 creator A5091663054 @default.
• W3138973995 date "2021-07-04" @default.
• W3138973995 modified "2023-09-25" @default.
• W3138973995 title "The pathological features of leukemic cells infiltrating the renal interstitium in chronic lymphocytic leukemia/small lymphocytic lymphoma from a large single Chinese center" @default.
• W3138973995 cites W1565211228 @default.
• W3138973995 cites W1729485532 @default.
• W3138973995 cites W1963866884 @default.
• W3138973995 cites W1978454290 @default.
• W3138973995 cites W1982589145 @default.
• W3138973995 cites W2023603647 @default.
• W3138973995 cites W2028305399 @default.
• W3138973995 cites W2030199606 @default.
• W3138973995 cites W2033972165 @default.
• W3138973995 cites W2038138703 @default.
• W3138973995 cites W2042120094 @default.
• W3138973995 cites W2045704840 @default.
• W3138973995 cites W2050210890 @default.
• W3138973995 cites W2055697803 @default.
• W3138973995 cites W2069369242 @default.
• W3138973995 cites W2077062621 @default.
• W3138973995 cites W2077532696 @default.
• W3138973995 cites W2087938915 @default.
• W3138973995 cites W2093328218 @default.
• W3138973995 cites W2098055806 @default.
• W3138973995 cites W2100871451 @default.
• W3138973995 cites W2120087999 @default.
• W3138973995 cites W2123471188 @default.
• W3138973995 cites W2142099365 @default.
• W3138973995 cites W2143446077 @default.
• W3138973995 cites W2144203487 @default.
• W3138973995 cites W2144851621 @default.
• W3138973995 cites W2152853007 @default.
• W3138973995 cites W2154992334 @default.
• W3138973995 cites W2163785293 @default.
• W3138973995 cites W2164450497 @default.
• W3138973995 cites W2166257417 @default.
• W3138973995 cites W2167626803 @default.
• W3138973995 cites W2171605408 @default.
• W3138973995 cites W2176746630 @default.
• W3138973995 cites W2211888839 @default.
• W3138973995 cites W2310716991 @default.
• W3138973995 cites W2315519503 @default.
• W3138973995 cites W2774153604 @default.
• W3138973995 cites W2798012077 @default.
• W3138973995 cites W2886437386 @default.
• W3138973995 cites W3004452248 @default.
• W3138973995 doi "https://doi.org/10.1186/s13000-021-01120-4" @default.
• W3138973995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8254985" @default.
• W3138973995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34218814" @default.
• W3138973995 hasPublicationYear "2021" @default.
• W3138973995 type Work @default.
• W3138973995 sameAs 3138973995 @default.
• W3138973995 citedByCount "2" @default.
• W3138973995 countsByYear W31389739952022 @default.
• W3138973995 countsByYear W31389739952023 @default.
• W3138973995 crossrefType "journal-article" @default.
• W3138973995 hasAuthorship W3138973995A5008236609 @default.
• W3138973995 hasAuthorship W3138973995A5063193909 @default.
• W3138973995 hasAuthorship W3138973995A5074670181 @default.
• W3138973995 hasAuthorship W3138973995A5090366405 @default.
• W3138973995 hasAuthorship W3138973995A5091663054 @default.
• W3138973995 hasBestOaLocation W31389739951 @default.
• W3138973995 hasConcept C126322002 @default.
• W3138973995 hasConcept C142724271 @default.
• W3138973995 hasConcept C159654299 @default.
• W3138973995 hasConcept C163864487 @default.
• W3138973995 hasConcept C18031839 @default.
• W3138973995 hasConcept C203014093 @default.
• W3138973995 hasConcept C21957315 @default.
• W3138973995 hasConcept C2775934546 @default.
• W3138973995 hasConcept C2777938653 @default.
• W3138973995 hasConcept C2778461978 @default.
• W3138973995 hasConcept C2779338263 @default.
• W3138973995 hasConcept C2780091579 @default.
• W3138973995 hasConcept C2781087799 @default.
• W3138973995 hasConcept C542903549 @default.
• W3138973995 hasConcept C71924100 @default.
• W3138973995 hasConceptScore W3138973995C126322002 @default.
• W3138973995 hasConceptScore W3138973995C142724271 @default.
• W3138973995 hasConceptScore W3138973995C159654299 @default.
• W3138973995 hasConceptScore W3138973995C163864487 @default.
• W3138973995 hasConceptScore W3138973995C18031839 @default.
• W3138973995 hasConceptScore W3138973995C203014093 @default.
• W3138973995 hasConceptScore W3138973995C21957315 @default.
• W3138973995 hasConceptScore W3138973995C2775934546 @default.
• W3138973995 hasConceptScore W3138973995C2777938653 @default.
• W3138973995 hasConceptScore W3138973995C2778461978 @default.
• W3138973995 hasConceptScore W3138973995C2779338263 @default.
• W3138973995 hasConceptScore W3138973995C2780091579 @default.
• W3138973995 hasConceptScore W3138973995C2781087799 @default.
• W3138973995 hasConceptScore W3138973995C542903549 @default.
• W3138973995 hasConceptScore W3138973995C71924100 @default.
• W3138973995 hasFunder F4320321001 @default.
• W3138973995 hasIssue "1" @default.

• next