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• W3138976927 abstract "There is a great concern on potential adverse effects of exposure to perfluorooctane sulfonate (PFOS) in sensitive subpopulations, such as pregnant women, fetuses, and neonates, due to its reported transplacental and lactational transfer and reproductive and developmental toxicities in animals and humans.This study aimed to develop a gestational and lactational physiologically based pharmacokinetic (PBPK) model in rats and humans for PFOS to aid risk assessment in sensitive human subpopulations.Based upon existing PBPK models for PFOS, the present model addressed a data gap of including a physiologically based description of basolateral and apical membrane transporter-mediated renal reabsorption and excretion in kidneys during gestation and lactation. The model was calibrated with published rat toxicokinetic and human biomonitoring data and was independently evaluated with separate data. Monte Carlo simulation was used to address the interindividual variability.Model simulations were generally within 2-fold of observed PFOS concentrations in maternal/fetal/neonatal plasma and liver in rats and humans. Estimated fifth percentile human equivalent doses (HEDs) based on selected critical toxicity studies in rats following U.S. Environmental Protection Agency (EPA) guidelines ranged from 0.08 to 0.91μg/kg per day. These values are lower than the HEDs estimated in U.S. EPA guidance (0.51-1.6μg/kg per day) using an empirical toxicokinetic model in adults.The results support the importance of renal reabsorption/excretion during pregnancy and lactation in PFOS dosimetry and suggest that the derivation of health-based toxicity values based on developmental toxicity studies should consider gestational/lactational dosimetry estimated from a life stage-appropriate PBPK model. This study provides a quantitative tool to aid risk reevaluation of PFOS, especially in sensitive human subpopulations, and it provides a basis for extrapolating to other per- and polyfluoroalkyl substances (PFAS). All model codes and detailed tutorials are provided in the Supplemental Materials to allow readers to reproduce our results and to use this model. https://doi.org/10.1289/EHP7671." @default.
• W3138976927 created "2021-03-29" @default.
• W3138976927 creator A5026895542 @default.
• W3138976927 creator A5061095526 @default.
• W3138976927 date "2021-03-01" @default.
• W3138976927 modified "2023-10-10" @default.
• W3138976927 title "Development of a Gestational and Lactational Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctane Sulfonate (PFOS) in Rats and Humans and Its Implications in the Derivation of Health-Based Toxicity Values" @default.
• W3138976927 cites W1007495478 @default.
• W3138976927 cites W11864364 @default.
• W3138976927 cites W1191882190 @default.
• W3138976927 cites W122661615 @default.
• W3138976927 cites W1499307361 @default.
• W3138976927 cites W1841600388 @default.
• W3138976927 cites W1922506313 @default.
• W3138976927 cites W1966078713 @default.
• W3138976927 cites W1969107063 @default.
• W3138976927 cites W1970940769 @default.
• W3138976927 cites W1971106859 @default.
• W3138976927 cites W1975459543 @default.
• W3138976927 cites W1975902105 @default.
• W3138976927 cites W1976770880 @default.
• W3138976927 cites W1979141008 @default.
• W3138976927 cites W1979264461 @default.
• W3138976927 cites W1986194759 @default.
• W3138976927 cites W1986721460 @default.
• W3138976927 cites W1986810471 @default.
• W3138976927 cites W1989064042 @default.
• W3138976927 cites W1989298332 @default.
• W3138976927 cites W1992990880 @default.
• W3138976927 cites W1993102524 @default.
• W3138976927 cites W1993650845 @default.
• W3138976927 cites W1994092493 @default.
• W3138976927 cites W1996863157 @default.
• W3138976927 cites W1998832327 @default.
• W3138976927 cites W2000006754 @default.
• W3138976927 cites W2003400440 @default.
• W3138976927 cites W2004876929 @default.
• W3138976927 cites W2005804196 @default.
• W3138976927 cites W2006930091 @default.
• W3138976927 cites W2012812422 @default.
• W3138976927 cites W2017247003 @default.
• W3138976927 cites W2018632954 @default.
• W3138976927 cites W2019243524 @default.
• W3138976927 cites W2019929308 @default.
• W3138976927 cites W2022327625 @default.
• W3138976927 cites W2022665021 @default.
• W3138976927 cites W2022974922 @default.
• W3138976927 cites W2024064489 @default.
• W3138976927 cites W2032340290 @default.
• W3138976927 cites W2033438697 @default.
• W3138976927 cites W2033609748 @default.
• W3138976927 cites W2034003465 @default.
• W3138976927 cites W2037737569 @default.
• W3138976927 cites W2043672781 @default.
• W3138976927 cites W2045414418 @default.
• W3138976927 cites W2048192376 @default.
• W3138976927 cites W2048297771 @default.
• W3138976927 cites W2049985148 @default.
• W3138976927 cites W2051911680 @default.
• W3138976927 cites W2052221450 @default.
• W3138976927 cites W2054905061 @default.
• W3138976927 cites W2054931112 @default.
• W3138976927 cites W2055564344 @default.
• W3138976927 cites W2056006235 @default.
• W3138976927 cites W2057199097 @default.
• W3138976927 cites W2057310849 @default.
• W3138976927 cites W2057846222 @default.
• W3138976927 cites W2059663974 @default.
• W3138976927 cites W2061530915 @default.
• W3138976927 cites W2062760602 @default.
• W3138976927 cites W2066782716 @default.
• W3138976927 cites W2070530203 @default.
• W3138976927 cites W2072784993 @default.
• W3138976927 cites W2078284700 @default.
• W3138976927 cites W2078929235 @default.
• W3138976927 cites W2079379160 @default.
• W3138976927 cites W2086163909 @default.
• W3138976927 cites W2086563070 @default.
• W3138976927 cites W2087275243 @default.
• W3138976927 cites W2087547108 @default.
• W3138976927 cites W2088551370 @default.
• W3138976927 cites W2090278017 @default.
• W3138976927 cites W2090305068 @default.
• W3138976927 cites W2093823226 @default.
• W3138976927 cites W2095068130 @default.
• W3138976927 cites W2096247408 @default.
• W3138976927 cites W2098379965 @default.
• W3138976927 cites W2099456501 @default.
• W3138976927 cites W2100493261 @default.
• W3138976927 cites W2104103595 @default.
• W3138976927 cites W2104356041 @default.
• W3138976927 cites W2104577684 @default.
• W3138976927 cites W2104908006 @default.
• W3138976927 cites W2111464473 @default.
• W3138976927 cites W2114650813 @default.
• W3138976927 cites W2118176854 @default.
• W3138976927 cites W2120447865 @default.
• W3138976927 cites W2123187782 @default.
• W3138976927 cites W2133554081 @default.
• W3138976927 cites W2134883557 @default.

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