Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139007881> ?p ?o ?g. }
- W3139007881 endingPage "1314" @default.
- W3139007881 startingPage "1304" @default.
- W3139007881 abstract "Abstract Background Epidemiological studies of adult glioma have identified genetic syndromes and 25 heritable risk loci that modify individual risk for glioma, as well increased risk in association with exposure to ionizing radiation and decreased risk in association with allergies. In this analysis, we assess whether there is a shared genome-wide genetic architecture between glioma and atopic/autoimmune diseases. Methods Using summary statistics from a glioma genome-wide association studies (GWAS) meta-analysis, we identified significant enrichment for risk variants associated with gene expression changes in immune cell populations. We also estimated genetic correlations between glioma and autoimmune, atopic, and hematologic traits using linkage disequilibrium score regression (LDSC), which leverages genome-wide single-nucleotide polymorphism (SNP) associations and patterns of linkage disequilibrium. Results Nominally significant negative correlations were observed for glioblastoma (GB) and primary biliary cirrhosis (rg = −0.26, P = .0228), and for non-GB gliomas and celiac disease (rg = −0.32, P = .0109). Our analyses implicate dendritic cells (GB pHM = 0.0306 and non-GB pHM = 0.0186) in mediating both GB and non-GB genetic predisposition, with GB-specific associations identified in natural killer (NK) cells (pHM = 0.0201) and stem cells (pHM = 0.0265). Conclusions This analysis identifies putative new associations between glioma and autoimmune conditions with genomic architecture that is inversely correlated with that of glioma and that T cells, NK cells, and myeloid cells are involved in mediating glioma predisposition. This provides further evidence that increased activation of the acquired immune system may modify individual susceptibility to glioma." @default.
- W3139007881 created "2021-03-29" @default.
- W3139007881 creator A5007160329 @default.
- W3139007881 creator A5008606431 @default.
- W3139007881 creator A5012085802 @default.
- W3139007881 creator A5013947352 @default.
- W3139007881 creator A5014071257 @default.
- W3139007881 creator A5022550644 @default.
- W3139007881 creator A5022800990 @default.
- W3139007881 creator A5028989565 @default.
- W3139007881 creator A5050523491 @default.
- W3139007881 creator A5079610074 @default.
- W3139007881 creator A5082417116 @default.
- W3139007881 date "2021-03-20" @default.
- W3139007881 modified "2023-10-16" @default.
- W3139007881 title "Partitioned glioma heritability shows subtype-specific enrichment in immune cells" @default.
- W3139007881 cites W1765766961 @default.
- W3139007881 cites W1812256879 @default.
- W3139007881 cites W1844405070 @default.
- W3139007881 cites W1901450410 @default.
- W3139007881 cites W1977099733 @default.
- W3139007881 cites W1980991473 @default.
- W3139007881 cites W1989758632 @default.
- W3139007881 cites W1991704577 @default.
- W3139007881 cites W2013181888 @default.
- W3139007881 cites W2021478269 @default.
- W3139007881 cites W2023879989 @default.
- W3139007881 cites W2040547343 @default.
- W3139007881 cites W2067134710 @default.
- W3139007881 cites W2080215939 @default.
- W3139007881 cites W2112409097 @default.
- W3139007881 cites W2116832637 @default.
- W3139007881 cites W2135465849 @default.
- W3139007881 cites W2143625465 @default.
- W3139007881 cites W2146734178 @default.
- W3139007881 cites W2148977460 @default.
- W3139007881 cites W2153860431 @default.
- W3139007881 cites W2163749231 @default.
- W3139007881 cites W2222803572 @default.
- W3139007881 cites W2244701831 @default.
- W3139007881 cites W2297581298 @default.
- W3139007881 cites W2435906918 @default.
- W3139007881 cites W2566908060 @default.
- W3139007881 cites W2584218241 @default.
- W3139007881 cites W2594844507 @default.
- W3139007881 cites W2596548837 @default.
- W3139007881 cites W2602986494 @default.
- W3139007881 cites W2621015632 @default.
- W3139007881 cites W2733615542 @default.
- W3139007881 cites W2738021800 @default.
- W3139007881 cites W2765314233 @default.
- W3139007881 cites W2768144164 @default.
- W3139007881 cites W2769021315 @default.
- W3139007881 cites W2770443008 @default.
- W3139007881 cites W2785011476 @default.
- W3139007881 cites W2793252773 @default.
- W3139007881 cites W2796584001 @default.
- W3139007881 cites W2811205482 @default.
- W3139007881 cites W2887361912 @default.
- W3139007881 cites W2892561411 @default.
- W3139007881 cites W2896013175 @default.
- W3139007881 cites W2905145431 @default.
- W3139007881 cites W2906664418 @default.
- W3139007881 cites W2907099021 @default.
- W3139007881 cites W2923510053 @default.
- W3139007881 cites W2934565342 @default.
- W3139007881 cites W2944925209 @default.
- W3139007881 cites W2950598813 @default.
- W3139007881 cites W2951880440 @default.
- W3139007881 cites W2953357410 @default.
- W3139007881 cites W3020931461 @default.
- W3139007881 cites W4234865248 @default.
- W3139007881 doi "https://doi.org/10.1093/neuonc/noab072" @default.
- W3139007881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8328033" @default.
- W3139007881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33743008" @default.
- W3139007881 hasPublicationYear "2021" @default.
- W3139007881 type Work @default.
- W3139007881 sameAs 3139007881 @default.
- W3139007881 citedByCount "8" @default.
- W3139007881 countsByYear W31390078812021 @default.
- W3139007881 countsByYear W31390078812022 @default.
- W3139007881 countsByYear W31390078812023 @default.
- W3139007881 crossrefType "journal-article" @default.
- W3139007881 hasAuthorship W3139007881A5007160329 @default.
- W3139007881 hasAuthorship W3139007881A5008606431 @default.
- W3139007881 hasAuthorship W3139007881A5012085802 @default.
- W3139007881 hasAuthorship W3139007881A5013947352 @default.
- W3139007881 hasAuthorship W3139007881A5014071257 @default.
- W3139007881 hasAuthorship W3139007881A5022550644 @default.
- W3139007881 hasAuthorship W3139007881A5022800990 @default.
- W3139007881 hasAuthorship W3139007881A5028989565 @default.
- W3139007881 hasAuthorship W3139007881A5050523491 @default.
- W3139007881 hasAuthorship W3139007881A5079610074 @default.
- W3139007881 hasAuthorship W3139007881A5082417116 @default.
- W3139007881 hasBestOaLocation W31390078811 @default.
- W3139007881 hasConcept C104317684 @default.
- W3139007881 hasConcept C106208931 @default.
- W3139007881 hasConcept C135763542 @default.