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- W3139043621 endingPage "369" @default.
- W3139043621 startingPage "355" @default.
- W3139043621 abstract "Intervertebral disc (IVD) degeneration is characterised by catabolic and inflammatory processes that contribute largely to tissue degradation and chronic back pain. The disc cells are responsible for the pathological production of pro-inflammatory cytokines and catabolic enzymes leading to degeneration. However, this phenotypical change is poorly understood. Growing evidence in animal and human studies implicates Toll-like receptors (TLR) and their activation through danger-associated alarmins, found increasingly in degenerating IVDs. TLR signalling results in the release of pro-inflammatory cytokines and proteolytic enzymes that can directly cause IVD degeneration and back pain. This review aims to summarise the current literature on TLR activation in IVD degeneration and discuss potential treatment modalities to alleviate the inflammatory phenotype of disc cells in order to arrest IVD degeneration and back pain." @default.
- W3139043621 created "2021-03-29" @default.
- W3139043621 creator A5011808166 @default.
- W3139043621 creator A5028696068 @default.
- W3139043621 creator A5046387569 @default.
- W3139043621 creator A5056844156 @default.
- W3139043621 date "2021-03-19" @default.
- W3139043621 modified "2023-10-01" @default.
- W3139043621 title "For whom the disc tolls: intervertebral disc degeneration, back pain and toll-like receptors" @default.
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